Lung cancer is the most common cause of death from cancer among men and women in the U.S.A. Recent estimates suggest that approximately 44 million persons currently smoke, and another 44 million are former smokers. Interestingly enough, more lung cancers are now being diagnosed among former smokers than current smokers. As the trend toward smoking cessation increases, lung cancers from former smokers will increase by the year 2000. Furthermore, chemopreventive strategies against current smokers have been disappointing. Thus, in addition to smoking cessation, effective chemoprevention strategies in former smokers must be developed. The overall goal of this Program Project is to develop effective chemopreventive approaches to reduce the incidence of lung cancer, especially in former smokers at high risk. To make significant progress, we have developed tightly integrated clinical and laboratory studies to create a focused, comprehensive program. This program encompasses three major directions: 1. Identify effective chemopreventive agents to prevent lung cancer. Project 1: Chemoprevention Trial in Former Smokers with 13-cis- Retinoic Acid and alpha-Tocopherol 2. Assess and quantitate mutagen sensitivity, DNA repair capacity, and genotypic characteristics that indicate a high risk for lung cancer development. Project 2: Lung Cancer Susceptibility in Former Smokers 3. Understand the fundamental biological processes of lung carcinogenesis and mechanisms of retinoid action. Project 3: Genotypic and Phenotypic Biomarkers in Lung Carcinogenesis Project 4: Mechanisms of Lung Cancer Prevention by Retinoids Core components (Administration, Biostatistics, and Data Management; and Histology) provide the structure and expertise required for the successful integration and execution of these combined clinical and laboratory studies.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (SRC (22))
Program Officer
Perloff, Marjorie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas MD Anderson Cancer Center
Other Domestic Higher Education
United States
Zip Code
Tam, Alda L; Kim, Edward S; Lee, J Jack et al. (2013) Feasibility of image-guided transthoracic core-needle biopsy in the BATTLE lung trial. J Thorac Oncol 8:436-42
Hittelman, Walter N; Liu, Diane D; Kurie, Jonathan M et al. (2007) Proliferative changes in the bronchial epithelium of former smokers treated with retinoids. J Natl Cancer Inst 99:1603-12
Gu, Jian; Wu, Xifeng; Dong, Qiong et al. (2006) A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. Cancer 106:2716-24
Han, Ji-Youn; Liu, Diane D; Lee, J Jack et al. (2005) 9-cis-retinoic acid treatment increases serum concentrations of alpha-tocopherol in former smokers. Clin Cancer Res 11:2305-11
Lee, Ho-Young; Chang, Yoon Soo; Han, Ji-Youn et al. (2005) Effects of 9-cis-retinoic acid on the insulin-like growth factor axis in former smokers. J Clin Oncol 23:4439-49
Wu, Xifeng; Roth, Jack A; Zhao, Hua et al. (2005) Cell cycle checkpoints, DNA damage/repair, and lung cancer risk. Cancer Res 65:349-57
Tang, Ximing; Wu, Weiguo; Sun, Shi-Yong et al. (2004) Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells. Mol Cancer Res 2:685-91
Lu, Tao; Hittelman, Walter N (2004) Improvement and application of fluorescence inter-simple sequence repeat polymerase chain reaction for the study of subclonal growths in lung epithelial cell populations. Chest 125:110S-1S
Wu, Xifeng; Schabath, Matthew B; Spitz, Margaret R (2003) Myeloperoxidase promoter region polymorphism and lung cancer risk. Methods Mol Med 75:121-33
Chang, Yoon Soo; Wu, Weiguo; Walsh, Garrett et al. (2003) Enolase-alpha is frequently down-regulated in non-small cell lung cancer and predicts aggressive biological behavior. Clin Cancer Res 9:3641-4

Showing the most recent 10 out of 80 publications