The NIH Roadmap and NCI strategic plans repeatedly invoke the need for greater involvement of healthcare systems in research. Integrated delivery systems, which provide comprehensive care from prevention to palliation, can address key research questions about cancer prevention and control that cannot be answered in many other settings. A consortium of healthcare systems with internal research capabilities creates an unprecedented opportunity to study variations in policy and patterns of cancer prevention and care. In recognition of this potential, the National Cancer Institute issued a Request for Applications in 1997 to """"""""facilitate the conduct of NCI sponsored research on cancer prevention...detection... [and] treatment"""""""" through collaboration among health care delivery systems. In response a group of HMOs (10 collaborators initially, and 13 in the proposed application), formed the HMO Cancer Research Network (CRN), whose overall objective is to conduct research that improves the effectiveness of cancer prevention and treatment through research that identifies individual, provider, system and treatment factors that affect outcomes. We propose herein a research infrastructure and array of projects that capitalize on the unique facets and contributions of a network of delivery systems. The proposed Cancer Research Network consists of four cores, five projects, and a research emphasis on translation of cancer care innovations in community settings. The CRN infrastructure supports our overall goals through a rich, interconnected set of shared resources, and collectively, the projects exploit the CRN's geographic diversity and its sophisticated automated data capabilities. CRN projects are designed to pinpoint the ways in which community-based health care systems can best respond to their enrolled members by: 1) ensuring that they receive the right cancer prevention services;2) devising cancer prevention messages that are readily understood and used;3) providing treatment that is both effective and cost effective to those patients with cancer;and 4) responding holistically to patients'physical and psychosocial needs. Research in the CRN will be readily applicable across health care settings and will contribute to overall improvements in the quality of cancer care.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
3U19CA079689-12S2
Application #
8143166
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (J2))
Program Officer
Brown, Martin L
Project Start
1999-06-01
Project End
2012-04-30
Budget Start
2010-06-15
Budget End
2011-04-30
Support Year
12
Fiscal Year
2010
Total Cost
$999,999
Indirect Cost
Name
Group Health Cooperative
Department
Type
DUNS #
078198520
City
Seattle
State
WA
Country
United States
Zip Code
98101
Punglia, Rinaa S; Jiang, Wei; Lipsitz, Stuart R et al. (2018) Clinical risk score to predict likelihood of recurrence after ductal carcinoma in situ treated with breast-conserving surgery. Breast Cancer Res Treat 167:751-759
Lieu, Tracy A; Ray, G Thomas; Prausnitz, Stephanie R et al. (2017) Oncologist and organizational factors associated with variation in breast cancer multigene testing. Breast Cancer Res Treat 163:167-176
Hassett, Michael J; Uno, Hajime; Cronin, Angel M et al. (2017) Survival after recurrence of stage I-III breast, colorectal, or lung cancer. Cancer Epidemiol 49:186-194
Kimmick, Gretchen G; Major, Brittny; Clapp, Jonathan et al. (2017) Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503). Breast Cancer Res Treat 163:391-398
Buist, Diana S M; Field, Terry S; Banegas, Matthew P et al. (2017) Training in the Conduct of Population-Based Multi-Site and Multi-Disciplinary Studies: the Cancer Research Network's Scholars Program. J Cancer Educ 32:283-292
Engmann, Natalie J; Ergas, Isaac J; Yao, Song et al. (2017) Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study. Cancer Epidemiol Biomarkers Prev 26:1466-1469
Yao, Song; Zhang, Yali; Tang, Li et al. (2017) Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis. Breast Cancer Res Treat 161:501-513
Yao, Song; Kwan, Marilyn L; Ergas, Isaac J et al. (2017) Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival: A Case-Cohort Analysis in the Pathways Study. JAMA Oncol 3:351-357
Mazor, Kathleen M; Rubin, Donald L; Roblin, Douglas W et al. (2016) Health literacy-listening skill and patient questions following cancer prevention and screening discussions. Health Expect 19:920-34
Walsh, Kathleen; Ryan, Jamie; Daraiseh, Nancy et al. (2016) Errors and Nonadherence in Pediatric Oral Chemotherapy Use. Oncology 91:231-236

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