Abstract

) We have established the first practical murine model of the most common human cancer-basal cell carcinomas-by exposing the skin of ptc +/- mice to repeated ultraviolet light irradiation. We propose a series of experiments first to refine this model by varying the wavelength, the degree, and the frequency of irradiation. We will test several additional variables including the effects of alternative environmental insults that appear to provoke human basal cell carcinomas-ionizing irradiation and arsenic as well as chemical carcinogens. We will validate the utility of this model by assessing chemopreventive agents that have been studied on humans-retinoids, green tea aqueous extract, and low-fat diet and then will utilize the model to test for chemopreventive efficacy of tea preparations and inhibitors of COX-1 and of COX-2. We will also assess the influence of varied genetic backgrounds both on photoinduction of efficacy of chemopreventive agents. Lastly, we will survey human extracutaneous cancers aberrant hedgehog pathway signaling.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19CA081888-04
Application #
6616327
Study Section
Project Start
2002-07-19
Project End
2003-06-30
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Tang, Jean Y; Xiao, Tony Zheng; Oda, Yuko et al. (2011) Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. Cancer Prev Res (Phila) 4:744-51
Davari, Parastoo; Hebert, Jennifer L; Albertson, Donna G et al. (2010) Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice. Carcinogenesis 31:968-73
Tang, Jean Y; Wu, Angela; Linos, Eleni et al. (2010) High prevalence of vitamin D deficiency in patients with basal cell nevus syndrome. Arch Dermatol 146:1105-10
Tang, Jean Y; Aszterbaum, Michelle; Athar, Mohammad et al. (2010) Basal cell carcinoma chemoprevention with nonsteroidal anti-inflammatory drugs in genetically predisposed PTCH1+/- humans and mice. Cancer Prev Res (Phila) 3:25-34
So, Po-Lin; Fujimoto, Michele A; Epstein Jr, Ervin H (2008) Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis. Mol Cancer Ther 7:1275-84
Bickers, David R; Athar, Mohammad (2006) Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol 126:2565-75
So, Po-Lin; Langston, Alexander W; Daniallinia, Nancy et al. (2006) Long-term establishment, characterization and manipulation of cell lines from mouse basal cell carcinoma tumors. Exp Dermatol 15:742-50
Athar, Mohammad; Tang, Xiuwei; Lee, Juliette L et al. (2006) Hedgehog signalling in skin development and cancer. Exp Dermatol 15:667-77
Lee, Juliette Lois; Kim, Arianna; Kopelovich, Levy et al. (2005) Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. J Invest Dermatol 125:818-25
Vogt, Annika; Hebert, Jennifer; Hwang, Jimmy et al. (2005) Anti-rejection drug treatment increases basal cell carcinoma burden in Ptch1+/- mice. J Invest Dermatol 124:263-7

Showing the most recent 10 out of 26 publications