Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19CA113318-04
Application #
7737132
Study Section
Special Emphasis Panel (ZCA1-SRRB-K (J1))
Project Start
2008-05-01
Project End
2010-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
4
Fiscal Year
2008
Total Cost
$115,763
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Vamos, Mitchell; Welsh, Kate; Finlay, Darren et al. (2013) Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. ACS Chem Biol 8:725-32
Jackson 2nd, Roger S; Placzek, William; Fernandez, Ana et al. (2012) Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. Neoplasia 14:656-65
Zhai, Dayong; Godoi, Paulo; Sergienko, Eduard et al. (2012) High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1. J Biomol Screen 17:350-60
Lu, Desheng; Choi, Michael Y; Yu, Jian et al. (2011) Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A 108:13253-7
Hu, Qi; Nie, Aihua; Welsh, Kate et al. (2011) Novel X-linked inhibitor of apoptosis protein inhibitors as probes of apoptosis in biology and medicine. Exp Biol Med (Maywood) 236:247-51
Yamaguchi, Ryuji; Janssen, Edith; Perkins, Guy et al. (2011) Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. PLoS One 6:e24102
Simons, Peter C; Young, Susan M; Carter, Mark B et al. (2011) Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples. Nat Protoc 6:943-52
Holt, Sarah V; Brookes, Karen E; Dive, Caroline et al. (2011) Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. Oncol Rep 25:1177-81
Ravanan, Palaniyandi; Sano, Renata; Talwar, Priti et al. (2011) Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines. Mol Cancer Ther 10:1635-43
Carter, Bing Z; Mak, Duncan H; Schober, Wendy D et al. (2010) Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML. Blood 115:306-14

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