Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19DA011007-04
Application #
6359591
Study Section
Project Start
2000-05-01
Project End
2002-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
2000
Total Cost
$408,465
Indirect Cost
Name
Mclean Hospital
Department
Type
DUNS #
046514535
City
Belmont
State
MA
Country
United States
Zip Code
02478
Schindler, Charles W; Graczyk, Zofi; Gilman, Joanne P et al. (2007) Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys. Eur J Pharmacol 576:107-13
Mello, Nancy K; Mendelson, Jack H; Sholar, Michelle B et al. (2005) Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men. Neuropsychopharmacology 30:618-32
Rusovici, Daniela E; Negus, S Stevens; Mello, Nancy K et al. (2004) Kappa-opioid receptors are differentially labeled by arylacetamides and benzomorphans. Eur J Pharmacol 485:119-25
Zhang, Ao; Xiong, Wennan; Bidlack, Jean M et al. (2004) 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. J Med Chem 47:165-74
Bowen, Carrie A; Negus, S Stevens; Zong, Rushi et al. (2003) Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys. Neuropsychopharmacology 28:1125-39
Negus, S Stevens; Mello, Nancy K; Linsenmayer, David C et al. (2002) Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys. Psychopharmacology (Berl) 163:412-9
Schindler, C W; Gilman, J P; Bergman, J et al. (2002) Interactions between cocaine and dopamine agonists on cardiovascular function in squirrel monkeys. J Pharmacol Exp Ther 300:180-7
Mutschler, Nicole H; Bergman, Jack (2002) Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys. Psychopharmacology (Berl) 160:362-70
Neumeyer, J L; Gu, X H; van Vliet, L A et al. (2001) Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. Bioorg Med Chem Lett 11:2735-40
Neumeyer, J L; Mello, N K; Negus, S S et al. (2000) Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse. Pharm Acta Helv 74:337-44

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