Abstract

Project IV will focus on the aspects of brain activation and cognition that appear to be unusual in autism, namely on inter-cortical region integration or coordination. The main approach will be the use of fMRI studies, many of them event-related, to examine the location and relative time course of the activation in key cortical areas, particularly in tasks that require varying amounts of interprocess coordination. The main types of cognitive tasks to be studied include language comprehension, problem-solving and planning. Another component of this project examines the development of cognitive abilities in the age range of 9 to 14, again focusing on processes that integrate various streams of information. Finally, the project will develop a computational model of the cognition and brain activation in autism, using as a point of departure a new computational neuroarchitecture, 4CAPS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19HD035469-06
Application #
6684197
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2002-09-26
Project End
2007-05-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Lynn, Andrew C; Padmanabhan, Aarthi; Simmonds, Daniel et al. (2018) Functional connectivity differences in autism during face and car recognition: underconnectivity and atypical age-related changes. Dev Sci 21:
Heymann, Perrine; Northrup, Jessie B; West, Kelsey L et al. (2018) Coordination is key: Joint attention and vocalisation in infant siblings of children with Autism Spectrum Disorder. Int J Lang Commun Disord 53:1007-1020
Iverson, Jana M; Northrup, Jessie B; Leezenbaum, Nina B et al. (2018) Early Gesture and Vocabulary Development in Infant Siblings of Children with Autism Spectrum Disorder. J Autism Dev Disord 48:55-71
West, Kelsey L; Leezenbaum, Nina B; Northrup, Jessie B et al. (2017) The Relation Between Walking and Language in Infant Siblings of Children With Autism Spectrum Disorder. Child Dev :
LeBarton, Eve Sauer; Iverson, Jana M (2016) Associations between gross motor and communicative development in at-risk infants. Infant Behav Dev 44:59-67
Focaroli, Valentina; Taffoni, Fabrizio; Parsons, Shelby M et al. (2016) Performance of Motor Sequences in Children at Heightened vs. Low Risk for ASD: A Longitudinal Study from 18 to 36 Months of Age. Front Psychol 7:724
O'Hearn, Kirsten; Velanova, Katerina; Lynn, Andrew et al. (2016) Abnormalities in brain systems supporting individuation and enumeration in autism. Autism Res 9:82-96
LeBarton, Eve Sauer; Iverson, Jana M (2016) Gesture development in toddlers with an older sibling with autism. Int J Lang Commun Disord 51:18-30
Mosconi, Matthew W; Sweeney, John A (2015) Sensorimotor dysfunctions as primary features of autism spectrum disorders. Sci China Life Sci 58:1016-23
Northrup, Jessie B; Iverson, Jana M (2015) Vocal Coordination During Early Parent-Infant Interactions Predicts Language Outcome in Infant Siblings of Children with Autism Spectrum Disorder. Infancy 20:523-547

Showing the most recent 10 out of 59 publications