Introduction and Overview Our objective in this study is to evaluate the possible unintended consequences ofthe FDA decision to issue a warning regarding the prescribing of SSRIs to children and adolescents and require a BBW on antidepressant labels. Depression is prevalent among youth in the US and is a risk factor for suicide.(21) Thus, it is of critical importance that the public health implications of possible decreases in antidepressant treatment rates be fully understood. While much research has been conducted in this area, suboptimal study design, absence of long-term trend data, and/or lack of statistical power have left important questions about the effects ofthe warnings on suicidality unanswered. Below we review the important studies to date and highlight how our proposed research will fill gaps in our understanding ofthe relationships among FDA warnings (and associated media reports), antidepressant treatment in youth, and risk of suicidal behavior.
| Coleman, Karen J; Johnson, Eric; Ahmedani, Brian K et al. (2018) Predicting Suicide Attempts for Racial and Ethnic Groups of Patients During Routine Clinical Care. Suicide Life Threat Behav : |
| Lu, Christine Y; Penfold, Robert B; Toh, Sengwee et al. (2018) Near Real-time Surveillance for Consequences of Health Policies Using Sequential Analysis. Med Care 56:365-372 |
| Simon, Gregory E; Johnson, Eric; Lawrence, Jean M et al. (2018) Predicting Suicide Attempts and Suicide Deaths Following Outpatient Visits Using Electronic Health Records. Am J Psychiatry 175:951-960 |
| Rossom, Rebecca C; Simon, Greg E; Coleman, Karen J et al. (2018) Are wishes for death or suicidal ideation symptoms of depression in older adults? Aging Ment Health :1-7 |
| Lu, Christine Y; Simon, Gregory; Soumerai, Stephen B et al. (2018) Counter-Point: Early Warning Systems Are Imperfect, but Essential. Med Care 56:382-383 |
| Lu, Christine Y; Simon, Gregory; Soumerai, Stephen B (2018) Counter-Point: Staying Honest When Policy Changes Backfire. Med Care 56:384-390 |
| Waitzfelder, Beth; Stewart, Christine; Coleman, Karen J et al. (2018) Treatment Initiation for New Episodes of Depression in Primary Care Settings. J Gen Intern Med 33:1283-1291 |
| Ahmedani, Brian K; Peterson, Edward L; Hu, Yong et al. (2017) Major Physical Health Conditions and Risk of Suicide. Am J Prev Med 53:308-315 |
| Penfold, Robert B; Stewart, Christine; Simon, Gregory E et al. (2017) Antidepressant Use by Youth with Minimal or Mild Depression: Evidence from 3 Health Systems. Pediatr Qual Saf 2:e017 |
| Becerra, Tracy A; Massolo, Maria L; Yau, Vincent M et al. (2017) A Survey of Parents with Children on the Autism Spectrum: Experience with Services and Treatments. Perm J 21: |
Showing the most recent 10 out of 49 publications
