Increasing health care costs and disturbing gaps in quality of care make it imperative to identify and implement the most effective and efficient health care services. This need for effectiveness research to guide practice and policy is especially pressing in mental health. The arrival rate of new mental health treatments far exceeds our ability to compare them in traditional clinical trials. Meeting this demand for timely and relevant evidence will require transformation of research to increase generalizability while reducing research time and expense. New infrastructure and innovative research methods will be necessary to accomplish that transformation. We propose to develop a Mental Health Research Network (MHRN) including nine established public domain research centers based in integrated not-for-profit health systems. These systems provide care to a diverse population of 10 million people in 11 states, and they share rich and compatible data resources to support a range of effectiveness research. Diversity of member demographics, insurance coverage, and organization of health services make this network an ideal environment for studying variation in care, comparing effectiveness and cost of treatments across practice environments, and studying dissemination and health policies. Participating research centers are experienced in a wide range of clinical areas and research methods. Three years of funding will support development of a core infrastructure for collaborative effectiveness research in mental health and completion of 4 research projects that leverage that infrastructure in specific clinical areas. The 4 research projects include the following: 1) An observational study of practice variation in high- and low-value care for mood disorders, 2) A pilot effectiveness trial of behavioral activation therapy for perinatal depression, 3) A geographically and ethnically diverse autism registry for effectiveness studies, and 4) Longitudinal analysis of SSRI warnings and suicidality in youth. Our long-term objectives are to expand the MHRN to include additional health systems and external investigators, to conduct multi-site observational and experimental studies of comparative effectiveness, to develop and evaluate methods for dissemination and implementation, and to become a national resource of research methods and effectiveness evidence for researchers, patients, providers and healthcare leaders.

Public Health Relevance

We propose to develop a Mental Health Research Network (MHRN) including 9 established research centers based in integrated health care systems. The MHRN will complement traditional clinical research by taking advantage of large potential samples of patients, diverse patient care settings, access to large provider groups, and integrated data systems to conduct rapid and efficient effectiveness trials in mental health. The ultimate goal is to improve the public health impact of mental health research on the US population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program--Cooperative Agreements (U19)
Project #
3U19MH092201-03S1
Application #
8530627
Study Section
Special Emphasis Panel (ZMH1-ERB-B (02))
Program Officer
Chambers, David A
Project Start
2010-09-24
Project End
2014-07-31
Budget Start
2012-08-15
Budget End
2014-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$100,228
Indirect Cost
$20,452
Name
Group Health Cooperative
Department
Type
DUNS #
078198520
City
Seattle
State
WA
Country
United States
Zip Code
98101
Coleman, Karen J; Johnson, Eric; Ahmedani, Brian K et al. (2018) Predicting Suicide Attempts for Racial and Ethnic Groups of Patients During Routine Clinical Care. Suicide Life Threat Behav :
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Simon, Gregory E; Johnson, Eric; Lawrence, Jean M et al. (2018) Predicting Suicide Attempts and Suicide Deaths Following Outpatient Visits Using Electronic Health Records. Am J Psychiatry 175:951-960
Rossom, Rebecca C; Simon, Greg E; Coleman, Karen J et al. (2018) Are wishes for death or suicidal ideation symptoms of depression in older adults? Aging Ment Health :1-7
Lu, Christine Y; Simon, Gregory; Soumerai, Stephen B et al. (2018) Counter-Point: Early Warning Systems Are Imperfect, but Essential. Med Care 56:382-383
Lu, Christine Y; Simon, Gregory; Soumerai, Stephen B (2018) Counter-Point: Staying Honest When Policy Changes Backfire. Med Care 56:384-390
Waitzfelder, Beth; Stewart, Christine; Coleman, Karen J et al. (2018) Treatment Initiation for New Episodes of Depression in Primary Care Settings. J Gen Intern Med 33:1283-1291
Simon, Gregory E; Shortreed, Susan M; Johnson, Eric et al. (2017) Between-visit changes in suicidal ideation and risk of subsequent suicide attempt. Depress Anxiety 34:794-800
Dimidjian, Sona; Goodman, Sherryl H; Sherwood, Nancy E et al. (2017) A pragmatic randomized clinical trial of behavioral activation for depressed pregnant women. J Consult Clin Psychol 85:26-36
Rossom, Rebecca C; Coleman, Karen J; Ahmedani, Brian K et al. (2017) Suicidal ideation reported on the PHQ9 and risk of suicidal behavior across age groups. J Affect Disord 215:77-84

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