The Philippine Mollusk Symbiont ICBG (PMS-ICBG) harnesses the vast biodiversity of the Philippines to discover new drugs to treat bacterial infections, parasitic infections, pain and other neurological conditions and cancer, all of which are serious health problems in both the Philippines and the United States. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal needs, consequent urgent need for conservation, and government commitment to education and technology to harness national human and natural resources for a sustainable future. Our focus is mollusks and their microbial symbionts; mollusks are one of the most diverse groups of marine animals, and their associated bacteria represent an unexplored trove of chemical diversity. The PMS- ICBG will use our increasing understanding of the interactions between mollusk symbionts and their hosts to discover the most novel and useful molecules. The project will document and describe Philippine mollusk biodiversity and support training and infrastructure that provide the foundation for conservation of Philippine biodiversity. The project is led by Margo Haygood, marine microbiologist, Oregon Health & Science University in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Diliman; Baldomero Olivera, biochemist and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, malacologist, of the Academy of Natural Sciences, Drexel University, Daniel Distel, marine microbiologist, Northeastern University, and Roberta O'Connor, parasitologist, Tufts Medical Center.
Group Plan The vast biological diversity of the Philippines holds promise for discovery of new drugs. The Group Plan describes our overall plan to obtain new compounds that might hold therapeutic potential in treating diseases of the nervous system, cancer, parasitism, and infectious diseases.
| Torres, Joshua P; Tianero, Maria Diarey; Robes, Jose Miguel D et al. (2017) Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts. Appl Environ Microbiol 83: |
| Distel, Daniel L; Altamia, Marvin A; Lin, Zhenjian et al. (2017) Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory. Proc Natl Acad Sci U S A 114:E3652-E3658 |
| Lin, Zhenjian; Smith, Misty D; Concepcion, Gisela P et al. (2017) Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products. J Nat Prod 80:2360-2370 |
| Shipway, J R; O'Connor, R; Stein, D et al. (2016) Zachsia zenkewitschi (Teredinidae), a Rare and Unusual Seagrass Boring Bivalve Revisited and Redescribed. PLoS One 11:e0155269 |
| Barghi, Neda; Concepcion, Gisela P; Olivera, Baldomero M et al. (2015) Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus Exogenomes. Genome Biol Evol 7:1797-814 |
| Barghi, Neda; Concepcion, Gisela P; Olivera, Baldomero M et al. (2015) High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms. Mar Biotechnol (NY) 17:81-98 |
| Neves, Jorge L B; Lin, Zhenjian; Imperial, Julita S et al. (2015) Small Molecules in the Cone Snail Arsenal. Org Lett 17:4933-5 |
| Cragg, Simon M; Beckham, Gregg T; Bruce, Neil C et al. (2015) Lignocellulose degradation mechanisms across the Tree of Life. Curr Opin Chem Biol 29:108-19 |
| Teichert, Russell W; Schmidt, Eric W; Olivera, Baldomero M (2015) Constellation pharmacology: a new paradigm for drug discovery. Annu Rev Pharmacol Toxicol 55:573-89 |
| Puillandre, N; Duda, T F; Meyer, C et al. (2015) One, four or 100 genera? A new classification of the cone snails. J Molluscan Stud 81:1-23 |
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