This application proposes the establishment of a Collaborative Minority Alcohol Research Development (CMIARD) Program at Howard University. The goal is to stimulate, strengthen, and facilitate multi-disciplinary research and collaborations which will lead to the reduction of alcohol morbidity/mortality among minority populations with emphasis on African Americans. Under the theme of Ethnic Factors in Alcohol Abuse Among African Americans, Howard University will create a strong and effective infrastructure of facilities, staff, and an optimum research environment to (1) support new exploratory and ongoing research; (2) motivate and cultivate interest by well trained research investigatory in the area of alcohol research; (3) train students in the area of alcohol research; and (4) create and implement mechanisms for the transfer of pertinent information gleaned from the research to health professionals and the local and world community. The CMIARD will be housed within the Department of Pharmacology, Howard University College of Medicine and Hospital which will serve as the hub for the management of all administrative and scientific functions. Under the direction and leadership of the PI, an Administrative Core will be established with the following components: (1) a Project Advisory Committee (PAC) to provide overall direction and guidance, (2) an Executive Committee to serve as an adjunct to the PAC, assisting with general decision making and very timely input into the Centers operation, (3) Working Groups to include experienced scientists and new investigators to help stimulate interest in alcohol research, and (4) the Scientific Research Project component. The research component of the Administrative core have five initial research projects for inclusion in this application representing a broad spectrum of promising research. These projects are designed to further research in fetal alcohol syndrome, ethnogenetic determinants of alcohol abuse, and basic science experimental models of alcohols effects. Ten additional projects offer strong consideration for future research projects, a five year research plan is proposed which focuses on a well integrated, multi disciplinary approach to expand current and develop new research capabilities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24AA011898-04
Application #
6168681
Study Section
Special Emphasis Panel (ZAA1-AA (05))
Program Officer
Vanderveen, Ernestine
Project Start
1997-09-30
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
4
Fiscal Year
2000
Total Cost
$700,760
Indirect Cost
Name
Howard University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059
Cain, Gloria E; Kalu, Nnenna; Kwagyan, John et al. (2016) Beliefs and Preferences for Medical Research Among African-Americans. J Racial Ethn Health Disparities 3:74-82
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Marshall, Vanessa J; Kalu, Nnenna; Kwagyan, John et al. (2013) Alcohol dependence and health care utilization in African Americans. J Natl Med Assoc 105:42-9
Marshall, Vanessa J; Kalu, Nnenna; Kwagyan, John et al. (2012) Perceptions about genetic testing for the susceptibility to alcohol dependence and other multifactorial diseases. Genet Test Mol Biomarkers 16:476-81
Marshall, Vanessa J; McLaurin-Jones, TyWanda L; Kalu, Nnenna et al. (2012) Screening, brief intervention, and referral to treatment: public health training for primary care. Am J Public Health 102:e30-6
Taylor, Robert E; Raysor, Byron R; Kwagyan, John et al. (2008) Alterations in ethyl alcohol pharmacokinetics during oral consumption of malt liquor beverages in African Americans. Alcohol Clin Exp Res 32:2074-80
Scott, Denise M; Williams, Carla D; Cain, Gloria E et al. (2008) Clinical course of alcohol dependence in African Americans. J Addict Dis 27:43-50
Sobrian, Sonya K; Jones, Barbara L; James, Hutchinson et al. (2005) Prenatal ethanol preferentially enhances reactivity of the dopamine D1 but not D2 or D3 receptors in offspring. Neurotoxicol Teratol 27:73-93
Sobrian, Sonya K; Jones, Barbara L; Varghese, Shiny et al. (2003) Behavioral response profiles following drug challenge with dopamine receptor subtype agonists and antagonists in developing rat. Neurotoxicol Teratol 25:311-28

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