The National Cell Repository for Alzheimer's Disease (NCRAD) plays a key role in the National Institute on Aging's (NIA) efforts to identify those at risk for Alzheimer disease (AD) and develop improved treatments to delay or prevent disease onset. NCRAD was established as a cooperative agreement with the NIA to serve as the biospecimen core for all NIA-funded dementia studies. Under the advisement of NIA and the NCRAD Executive Committee (NEC), it is the mission of NCRAD to remove critical barriers hindering research progress to understand the etiology of dementia. To achieve this goal, NCRAD has two primary functions: sample banking and sample distribution. This application is in response to a request by NIA to continue the support for NCRAD (PAR-15-316). NCRAD will work closely with other national efforts in AD research to achieve the following specific aims:
Aim 1 : To provide a state-of-the-art central biospecimen repository for all NIA-funded dementia studies.
Aim 2 : To facilitate and foster sample sharing to all qualified investigators.

Public Health Relevance

This application proposes to renewal the National Cell Repository for Alzheimer Disease (NCRAD), an NIA funded repository for dementia-related studies. NCRAD will work closely with NIA, studies banking samples, as well as researchers requesting samples to ensure that the biospecimens banked at NCRAD are of the highest quality. These biospecimens will be used to perform research with the ultimate goal of developing new treatments for Alzheimer disease and other types of dementia.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Silverberg, Nina B
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
Schools of Medicine
United States
Zip Code
Koch, Manja; DeKosky, Steven T; Fitzpatrick, Annette L et al. (2018) Apolipoproteins and Alzheimer's pathophysiology. Alzheimers Dement (Amst) 10:545-553
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Kinnunen, Kirsi M; Cash, David M; Poole, Teresa et al. (2018) Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study. Alzheimers Dement 14:43-53
Katsumata, Yuriko; Nelson, Peter T; Estus, Steven et al. (2018) Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs. Neurobiol Aging 74:135-146
Chen, Jason A; Chen, Zhongbo; Won, Hyejung et al. (2018) Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases. Mol Neurodegener 13:41
Raghavan, Neha S; Brickman, Adam M; Andrews, Howard et al. (2018) Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Ann Clin Transl Neurol 5:832-842
Miller, Jason E; Shivakumar, Manu K; Risacher, Shannon L et al. (2018) Codon bias among synonymous rare variants is associated with Alzheimer's disease imaging biomarker. Pac Symp Biocomput 23:365-376
Miller, Jason E; Shivakumar, Manu K; Lee, Younghee et al. (2018) Rare variants in the splicing regulatory elements of EXOC3L4 are associated with brain glucose metabolism in Alzheimer's disease. BMC Med Genomics 11:76
Ikezu, Tsuneya; Chen, Cidi; DeLeo, Annina M et al. (2018) Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol 13:254-264
Roostaei, Tina; Felsky, Daniel; Nazeri, Arash et al. (2018) Genetic influence of plasma homocysteine on Alzheimer's disease. Neurobiol Aging 62:243.e7-243.e14

Showing the most recent 10 out of 422 publications