The Center for International Blood and Marrow Transplant Research (CIBMTR) is a clinical research program dedicated to addressing important issues in hematopoietic cell transplantation (HCT) by offering a unique resource of data and statistical expertise to the scientific community. The CIBMTR includes >400 HCT centers that share data on HCT outcomes and a Statistical Center that maintains a clinical database with information for more than 250,000 HCT recipients. These data and the analytic support available through the CIBMTR Statistical Center have led to successful completion of hundreds of studies. U24-CA76518 provides the primary support for these activities. This application requests funding for the next 5 years to support this resource in order to provide the biomedical community continued access to a high quality clinical database and statistical support to facilitate clinical research. Planned resource enhancements include development of electronic data acquisition technology to facilitate participation by a wide range of U.S. and non-U.S. HCT centers;collaboration with other domestic and international organizations to increase the data available to study transplantation for rare indications and new HCT technologies;collecting data on outcome of other therapeutic applications of hematopoietic stem cells;expanding data on late effects and long-term quality of life;and developing new biostatistical methodology to address the challenges, needs and opportunities in analyzing HCT outcomes. The CIBMTR is committed to meeting the needs of investigators in a rapidly evolving field. It has and will build on the infrastructure made possible by support from U24-CA76518 and partnership with others to better serve the research community. Activities during the current and previous funding cycles have led to not only many publications on important issues in HCT but also have created the opportunity for greatly expanded global collaboration in data exchange and observational HCT research and contributed substantially to the success of a U.S. multicenter clinical trials network in HCT. Enhancements already in progress and planned for the next funding cycle will allow more in-depth exploration of immunobiologic aspects of HCT and post-HCT QOL. In summary, the CIBMTR, with the support provided through U24-CA76518, continues to play a unique role in facilitating clinical research in HCT.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24CA076518-15
Application #
8245589
Study Section
Special Emphasis Panel (ZCA1-RTRB-L (J1))
Program Officer
Merritt, William D
Project Start
1998-03-01
Project End
2013-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
15
Fiscal Year
2012
Total Cost
$2,891,099
Indirect Cost
$490,454
Name
Medical College of Wisconsin
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
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Ahn, Kwang Woo; Sahr, Natasha; Kim, Soyoung (2018) Screening group variables in the proportional hazards model. Stat Probab Lett 135:20-25
Strouse, Christopher; Zhang, Ying; Zhang, Mei-Jie et al. (2018) Risk Score for the Development of Veno-Occlusive Disease after Allogeneic Hematopoietic Cell Transplant. Biol Blood Marrow Transplant 24:2072-2080
Elgarten, Caitlin W; Arnold, Staci D; Li, Yimei et al. (2018) Hospital-Level Variability in Broad-Spectrum Antibiotic Use for Children With Acute Leukemia Undergoing Hematopoietic Cell Transplantation. Infect Control Hosp Epidemiol 39:797-805
Eapen, Mary; Brazauskas, Ruta; Hemmer, Michael et al. (2018) Hematopoietic cell transplant for acute myeloid leukemia and myelodysplastic syndrome: conditioning regimen intensity. Blood Adv 2:2095-2103
Shah, Nirav N; Ahn, Kwang Woo; Litovich, Carlos et al. (2018) Outcomes of Medicare-age eligible NHL patients receiving RIC allogeneic transplantation: a CIBMTR analysis. Blood Adv 2:933-940
Keesler, Daniel A; St Martin, Andrew; Bonfim, Carmem et al. (2018) Bone Marrow versus Peripheral Blood from Unrelated Donors for Children and Adolescents with Acute Leukemia. Biol Blood Marrow Transplant 24:2487-2492
Lee, Catherine; Haneuse, Sebastien; Wang, Hai-Lin et al. (2018) Prediction of absolute risk of acute graft-versus-host disease following hematopoietic cell transplantation. PLoS One 13:e0190610
Sureda, Anna; Zhang, Mei-Jie; Dreger, Peter et al. (2018) Allogeneic hematopoietic stem cell transplantation for relapsed follicular lymphoma: A combined analysis on behalf of the Lymphoma Working Party of the EBMT and the Lymphoma Committee of the CIBMTR. Cancer 124:1733-1742
Kumar, S K; Dispenzieri, A; Fraser, R et al. (2018) Early relapse after autologous hematopoietic cell transplantation remains a poor prognostic factor in multiple myeloma but outcomes have improved over time. Leukemia 32:986-995

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