Abstract

Section V. Metabolic Pathophysiology Core (MFC) The MFC is divided into three subcores: Metabolic Regulation, Islet Isolation, and Tissue and In Vivo Imaging. The Metabolic Regulation Subcore uses state-of-the-art techniques to assess metabolism and energy balance in the conscious mouse or perfused organ. The Islet Isolation Subcore provides high quality islets to investigators and characterizes pancreatic islet function in vitro. The Tissue and In vivo Imaging Subcore provides sensitive optical imaging techniques to monitor in vivo real time kinetics of a metabolic process or to monitor the kinetics of gene expression in vivo. Details of animal procedures can be found in """"""""Vertebrate Animals"""""""" located at the end of the core description.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK059637-09
Application #
7885288
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
9
Fiscal Year
2009
Total Cost
$134,463
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Hunter, Roger W; Hughey, Curtis C; Lantier, Louise et al. (2018) Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase. Nat Med 24:1395-1406
Perez, Katia M; Curley, Kathleen L; Slaughter, James C et al. (2018) Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism. J Clin Endocrinol Metab 103:4265-4274
Creecy, Amy; Uppuganti, Sasidhar; Unal, Mustafa et al. (2018) Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age. Bone 110:204-214
Babaev, Vladimir R; Ding, Lei; Zhang, Youmin et al. (2018) Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice. Arterioscler Thromb Vasc Biol :ATVBAHA118312206
Zhang, Ming-Zhi; Wang, Suwan; Wang, Yinqiu et al. (2018) Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity. Hypertension 72:1172-1179
Santos Guasch, Gabriela L; Beeler, J Scott; Marshall, Clayton B et al. (2018) p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion. iScience 8:236-249
Kjøbsted, Rasmus; Hingst, Janne R; Fentz, Joachim et al. (2018) AMPK in skeletal muscle function and metabolism. FASEB J 32:1741-1777
Kovtun, Oleg; Tomlinson, Ian D; Bailey, Danielle M et al. (2018) Single Quantum Dot Tracking Illuminates Neuroscience at the Nanoscale. Chem Phys Lett 706:741-752
Russart, Kathryn L G; Huk, Danielle; Nelson, Randy J et al. (2018) Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion. Horm Behav 98:121-129
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374

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