Over the last 15 years, our group has successfully managed the coordinating and bioinformatics unit (CBU) for two NIDDK funded consortia, the Diabetic Complications Consortium (DiaComp 2001-present, formerly the Animal Models of Diabetic Complications Consortium) and the Mouse Metabolic Phenotyping Centers (MMPC, 2006-present). DiaComp provides an environment to foster communications and collaborations between investigator communities involved in diabetic complications research. Toward this goal, DiaComp sponsors annual meetings in complications-relevant scientific areas, solicits and funds pilot projects in high impact areas of complications research, and supports a website to serve the diabetic complications community. During the current five year funding cycle, the CBU was responsible for continuing support for DiaComp through the use of opportunity pools (funding), manage/maintain the website and phenotyping data and administratively organize the meetings and workshops sponsored by the DiaComp to engage the greater diabetic complications scientific community. In contrast, the MMPCs are charged with providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for the mouse. The MMPC provides state-of-the-art technologies to investigators for a fee, with their services including characterization of mouse metabolism, blood composition (including hormones), energy balance, eating and exercise, organ function and morphology, physiology and histology. Over the last ten years the two consortia have been managed by one CBU because of the NIH decision to integrate the activities of the two consortia during their second funding cycles. Our laboratory has been the CBU for both DiaComp (last 15 years) and the MMPC (last 10 years). The CBU is responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate their operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current DiaComp/MMPC CBU infrastructure to provide both DiaComp and MMPC with a robust and comprehensive service oriented solution that supports both the common and unique aspects of each.

Public Health Relevance

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is providing funds to establish the coordinating and bioinformatics unit (CBU) for the Mouse Metabolic Phenotyping Centers (MMPC) and Diabetic Complications Consortium (DiaComp) programs. The CBU will coordinate the interactions of the MMPC Center awardees, provide financial management for opportunity pool programs, interact with the Executive Steering Committees and External Evaluation Committees as well as provide national web portals for both the MMPC and DiaComp programs in order to disseminate information and provide an organizational infrastructure for the program. This application will provide the infrastructure for the CBU for the MMPC and DiaComp.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK076169-12
Application #
9513300
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Abraham, Kristin M
Project Start
2006-09-15
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
12
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Augusta University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
City
Augusta
State
GA
Country
United States
Zip Code
30912
Mina, Amir I; LeClair, Raymond A; LeClair, Katherine B et al. (2018) CalR: A Web-Based Analysis Tool for Indirect Calorimetry Experiments. Cell Metab 28:656-666.e1
Wang, Feng; Katagiri, Daisuke; Li, Ke et al. (2018) Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. Magn Reson Med 80:2655-2669
Li, Wen; Sasse, Kent C; Bayguinov, Yulia et al. (2018) Contractile Protein Expression and Phosphorylation and Contractility of Gastric Smooth Muscles from Obese Patients and Patients with Obesity and Diabetes. J Diabetes Res 2018:8743874
Corbit, Kevin C; Camporez, João Paulo G; Edmunds, Lia R et al. (2018) Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes 67:208-221
Gurley, Susan B; Ghosh, Sujoy; Johnson, Stacy A et al. (2018) Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy. Diabetes 67:2096-2106
Karim, Lamya; Moulton, Julia; Van Vliet, Miranda et al. (2018) Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes. Bone 114:32-39
Pastar, Irena; Wong, Lulu L; Egger, Andjela N et al. (2018) Descriptive vs mechanistic scientific approach to study wound healing and its inhibition: Is there a value of translational research involving human subjects? Exp Dermatol 27:551-562
Uddin, Md Imam; Jayagopal, Ashwath; Wong, Alexis et al. (2018) Real-time imaging of VCAM-1 mRNA in TNF-? activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles. Nanomedicine 14:63-71
Shukla, Vasudha C; Kuang, Tai-Rong; Senthilvelan, Abirami et al. (2018) Lab-on-a-Chip Platforms for Biophysical Studies of Cancer with Single-Cell Resolution. Trends Biotechnol 36:549-561
Mitrofanova, Alla; Molina, Judith; Varona Santos, Javier et al. (2018) Hydroxypropyl-?-cyclodextrin protects from kidney disease in experimental Alport syndrome and focal segmental glomerulosclerosis. Kidney Int 94:1151-1159

Showing the most recent 10 out of 181 publications