The goal of the promotion and outreach core is to facilitate an array of research collaborations, workshops, and other educational activities, along with visiting scientist opportunities as outlined in the RFA. We will develop a curricula targeted specifically at research fellows and junior faculty that interdigitates with existing training programs, including T32 training grants and institutional K Award programs. This will permit us to build a pipeline of future metabolomic investigators. A pilot feasibility program will be developed that will also leverage other NIH and institutional resources. To achieve our overall goals we will adopt a biphasic strategy. During the first two years our focus will be on developing and providing outstanding educational opportunities by working with internal experts and external collaborators with the needed skills. During the first year, while metabolomics infrastructure is being expanded to accommodate additional demand, we will establish the Pilot &Feasibility program. This will set the stage for expanded promotion and outreach activities during the next three years of the award. To meet our overall goal Aim 1 leverages existing relationships with other institutions to facilitate research collaborations, a visiting scientist program, workshops, and short-term courses and training to the broad scientific community at these locations. Planning will occur for expansion of the RCMRC activities beyond these institutions during the first two years with roll out in years 3 and beyond.
In Aim 2 we will work with leaders of the institutional training (T32) and career development (K) awards to develop a curricula and hands-on training program to strengthen metabolomics training at the participating institutions. This will build a pipeline of future metabolomics investigators. During the second half of the funding cycle we will develop specific individual K applications directed toward career development and metabolomics and a metabolomics T32 institutional training grant if there is sufficient interest/demand.
Aim 3 will provide pilot/feasibility funding for focused projects in a timely manner, allowing investigators to pursue novel, innovative research directions.
The aims outlined above are designed to meet the overall goals of RCMRC program. They are also designed to maximally leverage ongoing collaborations, training activities, and pilot feasibility resources. Importantly, they are modeled on a number of successful approaches the PI and his team have used over the years to facilitate scientific collaboration and grow new fields of research.

Public Health Relevance

The Promotion and Outreach Core outlines a series of educational activities and collaborations designed to develop the next generation of metabolomics investigators and generally grow this field of research. It includes educational activities and partnerships with other institutions and leverages ongoing inter-institutional collaborations. It is also supported by a strong pilot and feasibility program that will permit investigators new to metabolomics to generate preliminary data critical for extramural support.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
1U24DK100469-01
Application #
8694170
Study Section
Special Emphasis Panel (ZRG1-BST-F (50))
Project Start
Project End
Budget Start
2013-09-10
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$333,795
Indirect Cost
$123,861
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Luthra, Gauri; Vuckovic, Ivan; Bangdiwala, A et al. (2018) First and second trimester urinary metabolic profiles and fetal growth restriction: an exploratory nested case-control study within the infant development and environment study. BMC Pregnancy Childbirth 18:48
Smestad, John; Erber, Luke; Chen, Yue et al. (2018) Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism. iScience 2:63-75
Hale, Vanessa L; Jeraldo, Patricio; Mundy, Michael et al. (2018) Synthesis of multi-omic data and community metabolic models reveals insights into the role of hydrogen sulfide in colon cancer. Methods 149:59-68
Fukushima, Masanori; Dasgupta, Debanjali; Mauer, Amy S et al. (2018) StAR-related lipid transfer domain 11 (STARD11)-mediated ceramide transport mediates extracellular vesicle biogenesis. J Biol Chem 293:15277-15289
Robinson, Matthew M; Lowe, Val J; Nair, K Sreekumaran (2018) Increased Brain Glucose Uptake After 12 Weeks of Aerobic High-Intensity Interval Training in Young and Older Adults. J Clin Endocrinol Metab 103:221-227
Smestad, John; Hamidi, Oksana; Wang, Lin et al. (2018) Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma. Oncotarget 9:6109-6127
Lee, Sunhye; Keirsey, Katherine I; Kirkland, Rebecca et al. (2018) Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats. J Nutr 148:209-219
Tran, Lee; Kras, Katon A; Hoffman, Nyssa et al. (2018) Lower Fasted-State but Greater Increase in Muscle Protein Synthesis in Response to Elevated Plasma Amino Acids in Obesity. Obesity (Silver Spring) 26:1179-1187
Pak, Victoria M; Dai, Feng; Keenan, Brendan T et al. (2018) Lower plasma choline levels are associated with sleepiness symptoms. Sleep Med 44:89-96
Chang, Alice Y; Lalia, Antigoni Z; Jenkins, Gregory D et al. (2017) Combining a nontargeted and targeted metabolomics approach to identify metabolic pathways significantly altered in polycystic ovary syndrome. Metabolism 71:52-63

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