The common marmoset (Callithrix jacchus) has experienced unprecedented growth in research across the United States and is rapidly emerging as a likely keystone biomedical model system in the next chapter of scientific discovery. Over the past decade, the number of marmoset laboratories in the US has quadrupled. There are now over 40 Principal Investigators who use marmoset as the model system in their research. Neuroscience is the primary engine driving marmoset research today, as nearly three quarters of marmoset researchers in the US use this model species to examine molecular, systems or cognitive functions in normal and diseased brains. Although these grassroots have been successfully forged new paths of scientific inquiry using marmosets in the U.S., critical bottlenecks have emerged that threaten to thwart the continued growth of this emerging model system. We propose to establish a Bicoastal Marmoset Breeding center, with two breeding colonies, one on the East Coast at Johns Hopkins University (JHU) and the other on the West Coast at University of California at San Diego (UCSD). The Center aims to produce a large number of marmosets to supply the marmoset research community in the U.S. Because of the non-availability of air transport of NHP in U.S. and prohibitively expensive ground transportation of NHP between the east and west coast, these two breeding colonies are strategically located to support the marmoset community in regions near each colony. We believe such a center is needed to address the national shortage of marmosets in order for the marmoset model to realize its full potential as a keystone species in the next chapter of neuroscience that serves to accelerate the rate of discovery and better understand human neurological disease.

Public Health Relevance

A proper model system is crucial to advance the studies of human neuropsychiatric diseases. The proposed project will contribute to the research in this field by making critical resource available to neuroscience research community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
1U24MH123423-01
Application #
10029350
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Soyombo-Shoola, Abigail A
Project Start
2020-07-15
Project End
2025-05-31
Budget Start
2020-07-15
Budget End
2021-05-31
Support Year
1
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Biomedical Engineering
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205