This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): A previously awarded grant allowed the TNPRC to begin the development of SPF rhesus monkey breeding colonies to provide animals for AIDS research programs. The SPF program has resulted in the successful recruitment of close to 600 animals in the first year. The objective of this application is to request funds to allow the expansion of the present TNPRC SPF rhesus breeding colonies (SPF4) and the development of a specialized SPF colony (SPF9+) which are further characterized and well suited for the needs of AIDS research. These strategies will assist in alleviating the critical national shortage of well-characterized rhesus monkeys for the AIDS research effort. The expansion of the present SPF colonies of the TNPRC will be accomplished using several strategies. Funds have been requested in this application to allow for support of a portion of the currently unsupported source colony where SPF candidate animals are derived in order to assure their ready availability. Funds for viral screening of animals and renovation of housing enclosures to better fit the need of small social group housing have been requested to expand the SPF4 colonies. An SPF9+ colony modeled after the successful 'super clean' colony at the New England National Primate Research Center (NENPRC) will be developed in addition to the SPF4 colony. The TNPRC will further develop the model of the 'super clean' colony by adding the testing for a number of gastrointestinal tract agents. These agents were chosen based on their relevance to AIDS research and to their clinical importance to the long term success of nonhuman primate (NHP) breeding colonies. It is anticipated that by the end of the five-year period of this grant, if awarded, 1,097 rhesus monkeys will be assigned to theSPF4 colony and 50 animals will be assigned to the SPF9+ colony. The total number of SPF4 animals in the TNPRC colony from the present colony and the proposed colony in this application is anticipated to be in excess of 2,000 animals in five years.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tulane University
Internal Medicine/Medicine
Schools of Medicine
New Orleans
United States
Zip Code
Sestak, Karol (2018) Non-Human Primate Models of Enteric Viral Infections. Viruses 10:
Gaither, Amanda M; Baker, Kate C; Gilbert, Margaret H et al. (2014) Videotaped behavior as a predictor of clinical outcome in rhesus macaques (Macaca mulatta). Comp Med 64:193-9
Farkas, Tibor; Falkenstein, Kathrine P; Bohm, Rudolf P et al. (2012) High incidence of rhesus enteric calicivirus infections and diarrhea in captive juvenile macaques: a likely association. J Med Primatol 41:325-8
Sestak, Karol; Feely, Stephanie; Fey, Brittney et al. (2012) Experimental inoculation of juvenile rhesus macaques with primate enteric caliciviruses. PLoS One 7:e37973
Farkas, Tibor; Dufour, Jason; Jiang, Xi et al. (2010) Detection of norovirus-, sapovirus- and rhesus enteric calicivirus-specific antibodies in captive juvenile macaques. J Gen Virol 91:734-8
Springer, Danielle A; Phillippi-Falkenstein, Kathrine; Smith, Gary (2009) Retrospective analysis of wound characteristics and tetanus development in captive macaques. J Zoo Wildl Med 40:95-102
Bethune, Michael T; Ribka, Erin; Khosla, Chaitan et al. (2008) Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques. PLoS One 3:e1857
Bethune, Michael T; Borda, Juan T; Ribka, Erin et al. (2008) A non-human primate model for gluten sensitivity. PLoS One 3:e1614