The Analytical Resources Core (ARC) has been an integral part of the VMMPC since it was founded in 2001. The ARC will consist of four subcores: 1) Hormone Assay and Analytical Services; 2) Lipids, Lipoproteins, and Atherosclerosis (LLA); 3) Mouse Pathology; and 4) Metabolic Flux Analysis (MFA). Throughout its history the ARC has operated at capacity with usage by investigators both inside and outside Vanderbilt. The ARC will undergo two major changes this cycle. The first change is that mouse atherosclerosis and plaque composition analyses will be moved to the ARC where they will be part of the Lipids, Lipoproteins and Atherosclerosis (LLA) Subcore. The second modification to the ARC is the creation of the Metabolic Flux Analysis (MFA) Subcore. The MFA Subcore involves the use of newly developed stable isotopic methods to assess metabolic flux in the conscious mouse or in vitro model systems. The goals of the core are to provide controlled, precision services that streamline research activities, produce cost-effective lines of experimentation, foster collaborative enterprises, and provide alternative outlets to scientists reaching the technical limits of their own laboratories. The services offered by each subcore are unique in their application to the mouse, and great effort has been made to establish assay specificity and scale down sample size to accommodate samples from this species. The Core provides space, equipment, and personnel for sample analyses and methods development. Investigators pay a fee-for-service that covers the cost of reagents, supplies, a percentage of personnel salary, and service contracts.

Project Start
Project End
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
17
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
965717143
City
Nashville
State
TN
Country
United States
Zip Code
37240
Rojas, Juan D; Lin, Fanglue; Chiang, Yun-Chen et al. (2018) Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy. Theranostics 8:141-155
Lewis Jr, J S; Chernock, R D; Bishop, J A (2018) Squamous and Neuroendocrine Specific Immunohistochemical Markers in Head and Neck Squamous Cell Carcinoma: A Tissue Microarray Study. Head Neck Pathol 12:62-70
Mani, Bharath K; Castorena, Carlos M; Osborne-Lawrence, Sherri et al. (2018) Ghrelin mediates exercise endurance and the feeding response post-exercise. Mol Metab 9:114-130
McClatchey, Penn Mason; Mignemi, Nicholas A; Xu, Zhengang et al. (2018) Automated quantification of microvascular perfusion. Microcirculation :e12482
Wasserman, David H; Wang, Thomas J; Brown, Nancy J (2018) The Vasculature in Prediabetes. Circ Res 122:1135-1150
Huynh, Frank K; Hu, Xiaoke; Lin, Zhihong et al. (2018) Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. J Inherit Metab Dis 41:59-72
Creecy, Amy; Uppuganti, Sasidhar; Unal, Mustafa et al. (2018) Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age. Bone 110:204-214
Russart, Kathryn L G; Huk, Danielle; Nelson, Randy J et al. (2018) Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion. Horm Behav 98:121-129
Chen, Xi; Ayala, Iriscilla; Shannon, Chris et al. (2018) The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function. Diabetes 67:554-568
Williams, Ian M; Valenzuela, Francisco A; Kahl, Steven D et al. (2018) Insulin exits skeletal muscle capillaries by fluid-phase transport. J Clin Invest 128:699-714

Showing the most recent 10 out of 265 publications