? RESOURCE INFORMATICS The goal of RegulomeDB is the development and implementation of a comprehensive resource to explore the gene regulation at the nucleotide level. We will provide visualization tools that interconnect multiple datatypes. We will allow search of variants using a variety of file formats and allow batch submission for queries. We will adopt modern, efficient and open source technologies, software frameworks, massively parallel search methods, annotation-based data schema, API and web services. By becoming fully deployed from the Amazon Cloud we will provide all data via a data commons style tool box. Maintain the highest quality control, including auditing and validation with automatic testing of software and content.

Public Health Relevance

TO PUBLIC HEALTH, PROJECT NARRATIVE The regulation of gene expression controls the determination of cell types, and aberrant gene expression can cause diseases such as cancer. RegulomeDB will enable researchers, clinicians, and sophisticated computer programs to relate DNA variants that lie in previously poorly understood regions of the human genome to possible functions thereby helping us understand the genetic basis of human variation and disease.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Biotechnology Resource Cooperative Agreements (U41)
Project #
5U41HG009293-03
Application #
9626413
Study Section
National Human Genome Research Institute Initial Review Group (GNOM)
Project Start
Project End
Budget Start
2019-02-01
Budget End
2020-01-31
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304