Abstract

We believe that a comparison of proteins that are very closely related in sequence, but have different temperature/activity profiles will most likely yield useful information on the origins of ADK thermostability. On this basis we have proposed to carefully compare the three dimensional structures of three adenylate kinases . Station 14 BM-C was used to collect data under cryogenic conditions at a single wavelength close to I A.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Cooperative Agreements (U41)
Project #
5U41RR007707-08
Application #
6206343
Study Section
Project Start
1999-08-15
Project End
2000-08-14
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Durbin, S M; Clevenger, T; Graber, T et al. (2012) X-ray pump optical probe cross-correlation study of GaAs. Nat Photonics 6:111-114
Neutze, Richard; Moffat, Keith (2012) Time-resolved structural studies at synchrotrons and X-ray free electron lasers: opportunities and challenges. Curr Opin Struct Biol 22:651-9
Horsman, Geoff P; Ke, Jiyuan; Dai, Shaodong et al. (2006) Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway. Biochemistry 45:11071-86