Vinculin is large protein of MW 120 KDa, of unknown structure, which plays a central role in the assembly of focal adhesions. These are macromoleular complexes found at cell-matrix junctions, which provide a structural and functional link between the extracellular matrix and the actin cytoskeleton. Much is known about the binding activities of vinculin in vitro, and the field is well poised to benefit from structural data at atomic resolution, which would elucidate the structural basis of focal adhesion assembly and regulation

Project Start
2000-08-15
Project End
2001-08-14
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
9
Fiscal Year
2000
Total Cost
$6,861
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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Horsman, Geoff P; Ke, Jiyuan; Dai, Shaodong et al. (2006) Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway. Biochemistry 45:11071-86