This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Project SummaryWe propose to develop, implement, and validate use of a computerized control system for MR-monitored thermal therapies (interstitial laser thermal therapy and cryotherapy) that is to be attached to our 0.5T open configuration interventional MR scanner. The system will utilize 3D MRI information, providing audible and visual prior warning signals and an alarm signal at the therapy endpoint.
We aim to directly answer the cancer treatment clinical need for accurate 3D spatial-temporal monitoring and control of tumor thermal therapies in heterogeneous tissue, currently beyond human capability, to guarantee patient safety while optimizing therapy effectiveness. Our proposed system will provide recognizable prior warning signals before the endpoint is reached, and an alarm signal at the instance when the thermal therapy endpoint occurs, as the thermal exposure level or therapy boundary meets or exceeds predefined 3D boundaries or safety limits. Project Start: 01-AUG-2001 Project End: 31-JUL-2007 Plans Going ForwardEmphasis will be on beginning Trial Phase Two, the use of the control system in human cryotherapy cases. The system will be limited to using the (validated) optical flow-based prediction method for monitoring until the Software Module Two software is complete. The progress on Software Module Two appears to be slower than anticipated due to the software programming and software integration difficulties. Benefits of Collaboration to the NCIGTThe U41 provides aid to the project in that it supports the thermal therapies occuring in our MRT suite that are the prime target of the software developed in this project. Benefits to the ProjectThe project provides aid to the U41 Imaging and MR-guided therapy cores in that this project is a technical development project that should raise the technical and level of the capabilities available for thermal therapies at BWH. Publications Stuart G. Silverman, Maryellen R. M. Sun, Kemal Tuncali, Paul R. Morrison, Eric van Sonnenberg, Sridhar Shankar, Kelly H. Zou, Simon K. Warfield, 'Three-Dimensional Assessment of MRI-Guided Percutatneous Cryotherapy of Liver Metastases, American Journal of Roentgenology. R.Nakamura, K.Tuncali, P.R.Morrison, N.Hata, S.G.Silverman, R.Kikinis, F.A.Jolesz, G.P.Zientara, 'Control System for MR-Guided Cryotherapy - Short-Term Prediction of Therapy Boundary Using Automatic Segmentation and 3D Optical Flow', Lecture Notes in Computer Science (Springer-Verlag, Heidelberg), 7th Intl Conf. Medical Image Computing and Computer-Assisted Intervention MICCAI, Saint-Malo France, Sept 2004, Vol. 3217, Pt. II, pp.542-550. D.Mitsouras, W.S.Hoge, F.J.Rybicki, A.Edelman, G.P.Zientara, ' Non-Fourier Encoded Parallel MRI Using Multiple Receiver Coils', Magn Res Med, 52:321-328, 2004. AbstractsKemal Tuncali, Gary P Zientara, Ryoichi Nakamura, Paul R Morrison, Simon K Warfield, Stuart G Silverman, 3D Computerized Monitoring of MRI-guided Percutaneous Cryoablations: Validation of the System in an Animal Model and Retrospective Clinical Case Applications, Abstract for Radiological Society of North America's 91st Scientific Assembly and Annual Meeting, Chicago, Illinois, November 2005. K Tuncali, R Nakamura, EN Wildenberg, PR Morrison, SK Warfield, GP Zientara, SG Silverman, '3D Computerized Monitoring of Image-Guided Percutaneous Tumor Ablations: Validation of the System in an Animal Model and Retrospective Clinical Case Applications', Abstract for the 5th Interventional MRI Symposium, Boston, MA, October 2004. D. Mitsouras, R.V. Mulkern, A.S. Edelman, G.P.Zientara, F.J.Rybicki, '3D Ultra-Fast Spin Echo Inner Volume MRI: Neuroimaging Applications', Abstract for 12th Meeting Intl Society of Magnetic Resonance, Kyoto, Japan, May 2004. D Mitsouras , R V Mulkern, A Edelman, G P Zientara, F J Rybicki, 'Neuroimaging Applications of Tow Reduced Field of View 3D Fast Spin Echo Magnetic Resonance Imaging Methods with Ultrashort, Non-Selective, Hard-Pulse Refocusing Radiofrequency Pulses', Abstract for Radiological Society of North America's 90th Scientific Assembly and Annual Meeting, Chicago, Illinois, November 2004.
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