Abstract

, Core B: Viral Testing Core Genetically characterized rhesus macaques that are free of endemic viral pathogens have become the premier animal model for HIV/AIDS research, including studies on HIV pathogenesis, AIDS-related opportunistic infections, as well as the development of HIV treatments and vaccines. The establishment of specific pathogen-free (SPF) colonies also serves to protect animal caretakers from zoonotic diseases and improves overall animal health. However, the successful derivation and maintenance of SPF colonies is challenging and requires strict surveillance regimens over long periods of time. Therefore, the overall aim of the Viral Testing Core is to provide appropriate pathogen surveillance and implement state-of-the-art testing services, in order to maintain our SPF colonies free of disease. To do this, we will use proven virus screening algorithms combined with an expanding arsenal of screening assays. A central strategy to achieve this will be the implementation of a new multiplexed protein microarray assay platform for routine colony screening, which we have recently developed and validated at our center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD010426-16
Application #
9441878
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
16
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Hessell, Ann J; Shapiro, Mariya B; Powell, Rebecca et al. (2018) Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated SHIV challenges. J Virol :
Eghlidi, Dominique H; Luna, Selva L; Brown, Donald I et al. (2018) Gene expression profiling of the SCN in young and old rhesus macaques. J Mol Endocrinol 61:57-67
Hansen, Scott G; Zak, Daniel E; Xu, Guangwu et al. (2018) Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat Med 24:130-143
Oberst, Michael D; Augé, Catherine; Morris, Chad et al. (2018) Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein. Mol Cancer Ther 17:1024-1038
Rais, Maham; Wilson, Randall M; Urbanski, Henryk F et al. (2017) Androgen supplementation improves some but not all aspects of immune senescence in aged male macaques. Geroscience 39:373-384
Eghlidi, Dominique H; Garyfallou, Vasilios T; Kohama, Steven G et al. (2017) Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques. J Mol Endocrinol 59:141-149
Urbanski, Henryk F (2017) Effect of androgen supplementation on 24-hour activity-rest patterns of aged male rhesus macaques. Neurobiol Aging 54:100-102
DeGottardi, Maren Q; Okoye, Afam A; Vaidya, Mukta et al. (2016) Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol 197:1183-98
McBurney, Sean P; Sunshine, Justine E; Gabriel, Sarah et al. (2016) Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates. Vaccine 34:3500-7
Yee, JoAnn L; Vanderford, Thomas H; Didier, Elizabeth S et al. (2016) Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management. J Med Primatol 45:55-78

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