Abstract

, Overall A safe, effective vaccine continues to be the best hope for controlling the Human Immunodeficiency Virus (HIV) pandemic. Due to similarities between the Indian-origin rhesus macaque (Macaca mulatta) and human immune systems, vaccine development as well as other approaches for controlling AIDS are heavily dependent upon the SIV and SHIV macaque models. There is a continuing need for Indian-origin rhesus macaques to support this work. Efficient domestic breeding programs, effectively managed to produce well characterized animals, with enhanced usefulness in biomedical research offer the best solution to ensuring the supply of Indian-origin rhesus macaques for AIDS vaccine development and other treatment and pathogenesis studies. The purpose of this proposal is to provide support for the genetically characterized, specific pathogen free, Indian-origin rhesus macaque AIDS Research Colony resource that was established in 2001 at the Oregon National Primate Research Center.

Public Health Relevance

The specific aims in this proposal are designed to continue our current efforts to maintain a genetically diverse MHC-defined SPF Indian-origin rhesus macaque colony targeting AIDS-related research focused on the use of opportunistic viral agents as vaccine vectors, as well as other approaches to AIDS prevention and treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD010426-18
Application #
9873088
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Chang, Michael
Project Start
2013-01-01
Project End
2021-02-28
Budget Start
2020-03-01
Budget End
2021-02-28
Support Year
18
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Veterinary Sciences
Type
Primate Centers
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Hessell, Ann J; Shapiro, Mariya B; Powell, Rebecca et al. (2018) Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated SHIV challenges. J Virol :
Eghlidi, Dominique H; Luna, Selva L; Brown, Donald I et al. (2018) Gene expression profiling of the SCN in young and old rhesus macaques. J Mol Endocrinol 61:57-67
Hansen, Scott G; Zak, Daniel E; Xu, Guangwu et al. (2018) Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat Med 24:130-143
Oberst, Michael D; Augé, Catherine; Morris, Chad et al. (2018) Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein. Mol Cancer Ther 17:1024-1038
Rais, Maham; Wilson, Randall M; Urbanski, Henryk F et al. (2017) Androgen supplementation improves some but not all aspects of immune senescence in aged male macaques. Geroscience 39:373-384
Eghlidi, Dominique H; Garyfallou, Vasilios T; Kohama, Steven G et al. (2017) Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques. J Mol Endocrinol 59:141-149
Urbanski, Henryk F (2017) Effect of androgen supplementation on 24-hour activity-rest patterns of aged male rhesus macaques. Neurobiol Aging 54:100-102
McBurney, Sean P; Sunshine, Justine E; Gabriel, Sarah et al. (2016) Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates. Vaccine 34:3500-7
Yee, JoAnn L; Vanderford, Thomas H; Didier, Elizabeth S et al. (2016) Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management. J Med Primatol 45:55-78
DeGottardi, Maren Q; Okoye, Afam A; Vaidya, Mukta et al. (2016) Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol 197:1183-98

Showing the most recent 10 out of 52 publications