Abstract

, Core A: Husbandry and Management Core The U42 SPF 4 Rhesus macaque breeding colony for AIDS research produces MHC class-1 typed rhesus macaques (Macaca mulatta) who are negative to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV-1), simian retrovirus (type D restrovirus or SRV), and macacine herpesvirus-1 (BV). SPF4 Indian origin rhesus macaques are the premier animal model for HIV/AIDS research, including studies of HIV pathogenesis, AIDS-related opportunistic infections, and the development of HIV treatments and vaccines. Demand for this resource continues to grow, and is projected to increase over the grant cycle. A predictable supply of disease-free, genetically characterized nonhuman primates is critical in the fight against HIV/AIDs. The overall aim of the Husbandry and Management Core is to maintain the ONPRC Specific Pathogen Free (SPF) rhesus macaque breeding colony for AIDS research at a targeted population of 175 adult breeder females capable of producing at least 120 surplus animals annually for research use. To achieve this we will provide innovative team based management practices including new social monitoring strategies, a weight management program for at-risk infants, serologic assays for Mycobacterium tuberculosis screening, and introduction of an artificial insemination program to expand genetic diversity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
2U42OD010426-19
Application #
10083096
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2013-01-01
Project End
2025-02-28
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
19
Fiscal Year
2021
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Hessell, Ann J; Shapiro, Mariya B; Powell, Rebecca et al. (2018) Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated SHIV challenges. J Virol :
Eghlidi, Dominique H; Luna, Selva L; Brown, Donald I et al. (2018) Gene expression profiling of the SCN in young and old rhesus macaques. J Mol Endocrinol 61:57-67
Hansen, Scott G; Zak, Daniel E; Xu, Guangwu et al. (2018) Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat Med 24:130-143
Oberst, Michael D; Augé, Catherine; Morris, Chad et al. (2018) Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein. Mol Cancer Ther 17:1024-1038
Rais, Maham; Wilson, Randall M; Urbanski, Henryk F et al. (2017) Androgen supplementation improves some but not all aspects of immune senescence in aged male macaques. Geroscience 39:373-384
Eghlidi, Dominique H; Garyfallou, Vasilios T; Kohama, Steven G et al. (2017) Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques. J Mol Endocrinol 59:141-149
Urbanski, Henryk F (2017) Effect of androgen supplementation on 24-hour activity-rest patterns of aged male rhesus macaques. Neurobiol Aging 54:100-102
DeGottardi, Maren Q; Okoye, Afam A; Vaidya, Mukta et al. (2016) Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol 197:1183-98
McBurney, Sean P; Sunshine, Justine E; Gabriel, Sarah et al. (2016) Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates. Vaccine 34:3500-7
Yee, JoAnn L; Vanderford, Thomas H; Didier, Elizabeth S et al. (2016) Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management. J Med Primatol 45:55-78

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