Genetically-engineered mice (transgenics, knockout and knock-ins) have become invaluable to almost all fields of medicine. Because of the importance of GEM to understanding human development and diseases and to creating improved drugs and therapeutics, tens of thousands of GEM have been created over the last decade. The MMRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of GEM as a resource for the biomedical community. Since the MMRRC Network began as a fledging repository in 1999/2000, it has evolved into a major resource for the biomedical community with capabilities and a combined inventory of mouse lines and embryonic stem (ES) cells that exceeds the capacity of other mouse repositories worldwide. The overall goal of this proposal is to continue and expand these functions and capabilities of the Mutant Mouse Regional Resource Center (MMRRC) at the University of Missouri to provide biomedical investigators with the mouse models and related reagents they require for their research.

Public Health Relevance

Genetically-engineered mice (transgenics, knockout and knock-ins) have become invaluable to almost all fields of medicine. Because of the importance of GEM to understanding human development and diseases and to creating improved drugs and therapeutics, tens of thousands of GEM have been created over the last decade. The MMRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of GEM as a resource for the biomedical community.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD010918-14
Application #
8434162
Study Section
Special Emphasis Panel (ZRR1-CM-9 (01))
Program Officer
Mirochnitchenko, Oleg
Project Start
2000-05-01
Project End
2015-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
14
Fiscal Year
2013
Total Cost
$1,365,639
Indirect Cost
$424,141
Name
University of Missouri-Columbia
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
153890272
City
Columbia
State
MO
Country
United States
Zip Code
65211
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Hart, Marcia L; Ericsson, Aaron C; Franklin, Craig L (2017) Differing Complex Microbiota Alter Disease Severity of the IL-10-/- Mouse Model of Inflammatory Bowel Disease. Front Microbiol 8:792
Techasintana, Patsharaporn; Ellis, Jason S; Glascock, Jacqueline et al. (2017) The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4+ Th2 Differentiation. Immunohorizons 1:109-123
Brodeur, Amanda C; Roberts-Pilgrim, Anna M; Thompson, Kimberlee L et al. (2017) Transforming growth factor-?1/Smad3-independent epithelial-mesenchymal transition in type I collagen glomerulopathy. Int J Nephrol Renovasc Dis 10:251-259

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