The CNPRC has maintained a breeding colony of SPF Indian-origin rhesus macaques SPF for over nineteen years. This colony has two different levels of SPF rhesus. The population of Level 1 animals are negative for 4 persistent viruses, (SIV, SRV, STLV, and B virus). Level 2 animals are negative for 7 persistent viruses (SIV, SRV, STLV, SFV, RRV, RhCMV, and B virus). The goal of the Husbandry and Management Core is to expand the number of SPF Level 2 animals to meet the needs of AIDS funds investigators investigating interaction between the host microbiome and AIDS vaccine and therapies. The percentage of SPF2 animals will be increased while maintaining the overall colony size. The Husbandry and Management Core will work with the Viral Testing Core to evaluate the possible addition of 2 more viruses (Adeno-associated virus, Lymphocryptovirus) for SPF exclusion. We will also evaluate with the Genetics Management Core the addition of Mamu B*17 to the MHC typing panel for the colony. Finally, the Husbandry and Management Core will systematically collect fecal microbiome and peripheral lymphoid cells from SPF animals at their biannual physical exams to be maintained in the biorepository for use by investigators conducting HIV/AIDS research.

Project Start
2000-09-30
Project End
2024-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
21
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
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