The Human Tissue and Organ Research Resource (HTORR) is a division of the National Disease Research Interchange (NDRI), the only not-for-profit NIH-funded organization whose mission is to provide the biomedical research community with human tissues for research. NDRI has a unique 24/7 nationwide human tissue acquisition network of over 130 tissue source sites, including organ procurement organizations, tissue banks, eye banks, hospitals and individual donors registered with the NDRI private donor program. HTORR is an essential research resource that uses systems customized to meet individual researcher requests to recover and distribute a broad range of high quality normal and diseased human tissues recovered from a diverse donor pool. HTORR, will continue to enhance researcher service and meet the evolving and expanding needs of the research community through 1) Supporting HTORR?s service to the biomedical research community by providing customized customer service, improving the quality of human tissue collection, and enhancing communication to the biomedical research community 2) Providing HTORR with a Tissue Source Site (TSS) network to meet the changing needs of the scientific community by monitoring TSS performance against demand, providing TSS with the tools necessary for donor screening and tissue recovery, and collaborating with additional partners to access tissue from donors with specific diseases, and 3) Continuing to monitor and maintain adherence to laws, regulations, industry best practices, and standards regarding the donation of human tissue for research. In addition to the serving researchers studying a wide range of common diseases, HTORR will continue to provide human tissues to investigators studying rare diseases, including LAM, and HIV. Implementation of this plan will ensure uninterrupted service of high quality, well annotated normal and diseased human biospecimens to investigators from an established network of tissue source sites, in concert with the development and implementation of innovative project-focused initiatives designed to meet the evolving needs of the biomedical research community.

Public Health Relevance

The research demand for human tissues continues to grow and the HTORR program provides a unique service to biomedical investigators nationwide whose research requires human tissues, organs and well annotated data. Over the past 4 years nearly 500 scientific papers were published by scientists who used HTORR-provided tissues, confirming HTORR's indispensable contribution to the biomedical research community and the impact of these services on the search for new treatments and cures for common and rare diseases, including HIV/AIDS.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
3U42OD011158-30S2
Application #
10175273
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Murphy, Stephanie
Project Start
1989-01-09
Project End
2023-06-30
Budget Start
2020-09-01
Budget End
2021-06-30
Support Year
30
Fiscal Year
2020
Total Cost
Indirect Cost
Name
National Disease Research Interchange
Department
Type
DUNS #
189136955
City
Philadelphia
State
PA
Country
United States
Zip Code
19102
Teitelbaum, A M; Murphy, S E; Akk, G et al. (2018) Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. Pharmacogenomics J 18:136-143
Gerli, Mattia Francesco Maria; Guyette, Jacques Paul; Evangelista-Leite, Daniele et al. (2018) Perfusion decellularization of a human limb: A novel platform for composite tissue engineering and reconstructive surgery. PLoS One 13:e0191497
Dhandapani, Rahul; Arokiaraj, Cynthia Mary; Taberner, Francisco J et al. (2018) Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nat Commun 9:1640
Chaudhary, Kapil; Promsote, Wanwisa; Ananth, Sudha et al. (2018) Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression. Sci Rep 8:3025
Sharif, Rabab; Sejersen, Henrik; Frank, Garrett et al. (2018) Effects of collagen cross-linking on the keratoconus metabolic network. Eye (Lond) 32:1271-1281
Lee, Albert; Karamichos, Dimitrios; Onochie, Obianamma E et al. (2018) Hypoxia modulates the development of a corneal stromal matrix model. Exp Eye Res 170:127-137
Sathyamurthy, Anupama; Johnson, Kory R; Matson, Kaya J E et al. (2018) Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior. Cell Rep 22:2216-2225
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Spurgeon, Megan E; den Boon, Johan A; Horswill, Mark et al. (2017) Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen. Proc Natl Acad Sci U S A 114:E9076-E9085
Thieme, Karina; Majumder, Syamantak; Brijmohan, Angela S et al. (2017) EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease. Sci Rep 7:3442

Showing the most recent 10 out of 32 publications