This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The Human Tissues and Organs for Research (HTOR) program of the NDRI is dedicated solely to accessing and providing human tissues for research purposes. These tissues and organs are essential for the great majority of research projects served by HTOR and the program is clearly relevant to advancing human health. HTOR's long-term objective is to increase the quantity, diversity, and quality of human research tissues available for research. The collection, preparation, and preservation of the tissues must be performed according to researcher-specified protocols for the materials to be useful to scientists. The acquisition of these materials requires an extensive national network of acquisition sites such as hospital pathology and surgical services, eye and tissue banks, and Organ Procurement Organizations. HTOR's unique systems ensure that tissues procured for customized protocols are delivered in a timely manner to the appropriate research destinations. The quantity, quality and diversity of tissues shipped to investigators is a function of three critical variables: the number and types of sources working with HTOR, the internal systems of HTOR, and the number and types of research requests that HTOR receives from researchers.
The specific aims of the proposed funding period focus on strengthening these three arms of the HTOR program (sources, information systems, and researchers). HTOR will work to increase the capabilities of existing sources and add new sources to increase tissue quantity and diversity (Specific Aim 1/Sources);upgrade HTOR's internal systems (computer hardware, software, and data management) to improve data capture and analysis, and upgrade the HTOR Web Site to increase Source and Researcher access to HTOR resources (Specific Aim 2/Systems);and work closely with the research community to fulfill existing and emerging needs for human research tissue (Specific Aim 3/Researchers). In addition, HTOR will continue a specialized program for procuring and distributing HIV positive tissues (Specific Aim 4), a goal that is also consistent with HTOR's long-term objective.

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Pino, Christopher J; Westover, Angela J; Buffington, Deborah A et al. (2017) Bioengineered Renal Cell Therapy Device for Clinical Translation. ASAIO J 63:305-315
Westover, Angela J; Buffington, Deborah A; Johnston, Kimberly A et al. (2017) A bio-artificial renal epithelial cell system conveys survival advantage in a porcine model of septic shock. J Tissue Eng Regen Med 11:649-657
Dezzutti, Charlene S; Else, Laura J; Yandura, Sarah E et al. (2016) Distinct Pharmacodynamic Activity of Rilpivirine in Ectocervical and Colonic Explant Tissue. Antimicrob Agents Chemother 60:2765-70
Catterall, J B; Zura, R D; Bolognesi, M P et al. (2016) Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage. Osteoarthritis Cartilage 24:374-81
Camci-Unal, Gulden; Newsome, David; Eustace, Brenda K et al. (2016) Fibroblasts Enhance Migration of Human Lung Cancer Cells in a Paper-Based Coculture System. Adv Healthc Mater 5:641-7, 626
Scott, Yanille M; Park, Seo Young; Dezzutti, Charlene S (2016) Broadly Neutralizing Anti-HIV Antibodies Prevent HIV Infection of Mucosal Tissue Ex Vivo. Antimicrob Agents Chemother 60:904-12
Wong, Marco D; Bingham, Karen; Moss, Emma et al. (2016) Recombinant Human Elastase Treatment of Cephalic Veins. Cardiovasc Pharm Open Access 5:
Blouw, Barbara; Patel, Manishha; Iizuka, Shinji et al. (2015) The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo. PLoS One 10:e0121003
Dezzutti, Charlene S; Yandura, Sarah; Wang, Lin et al. (2015) Pharmacodynamic Activity of Dapivirine and Maraviroc Single Entity and Combination Topical Gels for HIV-1 Prevention. Pharm Res 32:3768-81
Sroga, Gra?yna E; Wu, Ping-Cheng; Vashishth, Deepak (2015) Insulin-like growth factor 1, glycation and bone fragility: implications for fracture resistance of bone. PLoS One 10:e0117046

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