The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild. Most notably, Nations of the Convention on International Trade in Endangered Species (CITES) have specifically prohibited the importation of chimpanzees from the wild for research purposes; and the National Institutes of Health (NIH) created the `Chimpanzee Breeding and Research Program (CBRP). In 1986, the CBRP was created to insure a chimpanzee population in the United States for use in human health research. The University of Louisiana at Lafayette has been active in this endeavor since its conception. Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV). In addition they play a critical role in the evaluation of thepharmacodynamics, pharmacokinetics, bioavailablity, safety, and efficacy of novel drug compounds, proteins and monoclonal antibodies.
Specific aims of the application include the following: * To maintain capabilities to successfully breed (once the breeding moratorium has been lifted) and house chimpanzees in UL Lafayette-NIRC's CBRP AAALAC International-accredited colony * To conduct a longitudinal study to examine neurochemical and neuroendocrine correlates of aggressive and affiliative/social behavior and determine how position in the dominance hierarchy is associated with these parameters. * To collaborate and share data freely with the chimpanzee database grantees, investigators whose efforts would be supported by access to UL Lafayette's information and the ChiMP Coordinator, and to work with the ChiMP Advisory, Panel in developing long term plans for research use, breeding colony size, demographics, genetics, and long-term care. * To support national and international efforts to share biomedical research resources consistent with the National Institutes of Health's policy on Sharing of Model Organisms for Biomedical Research, and to enhance the development of and access to chimpanzee animal models critical to understanding human health needs consistent with NCRR's 2004-2008 Strategic Plan.

Project Start
2008-09-01
Project End
2009-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
8
Fiscal Year
2008
Total Cost
$200,116
Indirect Cost
Name
University of Louisiana at Lafayette
Department
Type
Other Domestic Higher Education
DUNS #
799451273
City
Lafayette
State
LA
Country
United States
Zip Code
70503
Zhou, Xiang; Cain, Carolyn E; Myrthil, Marsha et al. (2014) Epigenetic modifications are associated with inter-species gene expression variation in primates. Genome Biol 15:547
Reno, Philip L; McLean, Cory Y; Hines, Jasmine E et al. (2013) A penile spine/vibrissa enhancer sequence is missing in modern and extinct humans but is retained in multiple primates with penile spines and sensory vibrissae. PLoS One 8:e84258
Ferguson, William; Dvora, Shira; Fikes, Ronald W et al. (2012) Long-term balancing selection at the antiviral gene OAS1 in Central African chimpanzees. Mol Biol Evol 29:1093-103
McIntosh, Annick M; Bennett, Calvin; Dickson, Dara et al. (2012) The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes). PLoS One 7:e47760
Cain, Carolyn E; Blekhman, Ran; Marioni, John C et al. (2011) Gene expression differences among primates are associated with changes in a histone epigenetic modification. Genetics 187:1225-34
Callendret, BenoƮt; Bukh, Jens; Eccleston, Heather B et al. (2011) Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8? T cells in early viral evolution. J Virol 85:11833-45
Perry, George H; Marioni, John C; Melsted, Pall et al. (2010) Genomic-scale capture and sequencing of endogenous DNA from feces. Mol Ecol 19:5332-44
Stone, Anne C; Battistuzzi, Fabia U; Kubatko, Laura S et al. (2010) More reliable estimates of divergence times in Pan using complete mtDNA sequences and accounting for population structure. Philos Trans R Soc Lond B Biol Sci 365:3277-88
Claw, Katrina G; Tito, Raul Y; Stone, Anne C et al. (2010) Haplotype structure and divergence at human and chimpanzee serotonin transporter and receptor genes: implications for behavioral disorder association analyses. Mol Biol Evol 27:1518-29
Fontenot, M B; Musso, M W; Watson, S L et al. (2010) Characterization of cerebrospinal fluid monoamine metabolites in peripubertal chimpanzees (Pan troglodytes). J Med Primatol 39:24-31

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