This proposal for a cooperative agreement will establish collaborative partnerships between the UNC-Bowles Center for Alcohol Studies (UNC-ARC) and NCCU-BBRI faculty. The program administrators of the National Institute on Alcohol Abuse and Alcoholism will be involved in steering the program. These partnerships were developed to perfectly fit the long-range goal of the Collaborative Minority Alcohol Research Center Development (CMARCD) Program. That is to strengthen the alcohol research capacity of minority serving institutions. These collaborations are structured to integrate research between laboratories leading to common collaborative discoveries, with the overall objective to strengthen alcohol research programs at both institutions. This proposal represents a true collaborative effort between NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this CMARCD Program to conduct research on the Mechanisms of Alcohol Pathology (MAP). The MAP-Administrative Core (MAP-AC) is responsible for the overall implementation, management, coordination and support of the jointly developed research components (Figure 1), as well as coordination with the UNC-ARC's Administrative Core. The objective is to ensure a cohesive seamless administration of the overall partnership. This cohesiveness is essential to the fulfillment of the partnership's goals and objectives. The overall coordination, planning and evaluation of the partnership will be through the Steering Committee (SC). The SC will advise the MAP-AC on implementation, coordination and management of the cooperative agreement program. The administrative core of this cooperative agreement is organized to manage, direct and coordinate research, training and outreach-education activities. The Administrative core will provide leadership for the conduct of competitive alcohol research at NCCU in collaboration with UNC-ARC. The administrative core will support the Co-Directors in their goals to integrate research themes, promote collaborations, introduce new methodologies and help train and advise individuals on research techniques, career paths, productive experimental designs and aspects of publication and review. It will be a catalytic stimulus for enhancing and promoting alcohol research at NCCU in collaboration with the experienced UNC-ARC faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AA019767-05
Application #
8702045
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Vetreno, Ryan P; Lawrimore, Colleen J; Rowsey, Pamela J et al. (2018) Persistent Adult Neuroimmune Activation and Loss of Hippocampal Neurogenesis Following Adolescent Ethanol Exposure: Blockade by Exercise and the Anti-inflammatory Drug Indomethacin. Front Neurosci 12:200
Khatri, Dal; Laroche, Genevieve; Grant, Marion L et al. (2018) Acute Ethanol Inhibition of Adult Hippocampal Neurogenesis Involves CB1 Cannabinoid Receptor Signaling. Alcohol Clin Exp Res 42:718-726
Coleman Jr, Leon G; Zou, Jian; Qin, Liya et al. (2018) HMGB1/IL-1? complexes regulate neuroimmune responses in alcoholism. Brain Behav Immun 72:61-77
Coleman Jr, Leon G; Crews, Fulton T (2018) Innate Immune Signaling and Alcohol Use Disorders. Handb Exp Pharmacol 248:369-396
Vetreno, Ryan P; Yaxley, Richard; Paniagua, Beatriz et al. (2017) Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment. Addict Biol 22:712-723
Crews, Fulton T; Walter, T Jordan; Coleman Jr, Leon G et al. (2017) Toll-like receptor signaling and stages of addiction. Psychopharmacology (Berl) 234:1483-1498
Liu, Wen; Crews, Fulton T (2017) Persistent Decreases in Adult Subventricular and Hippocampal Neurogenesis Following Adolescent Intermittent Ethanol Exposure. Front Behav Neurosci 11:151
Fish, Eric W; Murdaugh, Laura B; Sulik, Kathleen K et al. (2017) Genetic vulnerabilities to prenatal alcohol exposure: Limb defects in sonic hedgehog and GLI2 heterozygous mice. Birth Defects Res 109:860-865
Coleman Jr, Leon G; Zou, Jian; Crews, Fulton T (2017) Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. J Neuroinflammation 14:22
Lawrimore, Colleen J; Crews, Fulton T (2017) Ethanol, TLR3, and TLR4 Agonists Have Unique Innate Immune Responses in Neuron-Like SH-SY5Y and Microglia-Like BV2. Alcohol Clin Exp Res 41:939-954

Showing the most recent 10 out of 33 publications