Bacterial quorum sensing involves small molecule ciamong individual cells in a population. Quorum s<Burkholderia mallei holds a particular interest. First, IIIaeruginosa quorum sensing is involved in virulencequorum sensing inhibitors have been hindered by thinfections. The availability of such models for fi. mallewill eventually lead to tests of efficacy for small molebelief among scientists working on quorum sensing isdiscriminate between a host and a free-living state, fino known environmental reservoir. Quorum sensing mtypes of infections by this pathogen. Finally, a most <anti-S. mallei therapeutic development. Dr. Greenbersensing reporter system for use in a high-throughput sat identification of quorum-controlled fi. mallei getechnology and require the construction of a quorum-jclosely related fi. thailandensis. A new counter-selethailandensis will be described, as will plans to extendmutations in members of the B. mallei group represobstacle faced by fi. mallei biologists.3ll-cell signaling that allows coordination of behaviorsnsing in the NIAID Category B Priority Pathogen<e for certain other pathogens such as Pseudomonasof fi. mallei. Efforts to develop anti-Pseucfomo/iase lack of adequate animal models for Pseudomonasi affords us the ability to put a program in motion thatcule inhibitors in animal models. Second, a common> that it allows a pathogen (or at least a symbiont) tojrkholderia mallei is an obligate animal pathogen withust be involved in discrimination of different stages orDbviously, quorum sensing in fi. ma//e/ is a target forg proposes to adapt his recently developed quorumcreen for inhibitors. Further experiments will be aimednes. These experiments will involve promoter-trapsensing regulator 'gutted strain of fi. mallei and or theaction method for insertional gene inactivation in fi.the procedure to fi. mallei. This method for generating>ents a major advance that will overcome a current
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