The overall objective of the Pulmonary Infection and Inflammation Core is to provide small animal aerosolchallenge models that support the research, career development, and developmental projects of the RCE.This Core brings together scientists with extensive experience in studying the molecular and cellularimmunology and pathology of the lungs using aerosol challenge models in normal and genetically alteredanimals. The Core will provide state-of-the-art technical support, facilities, and collaborative expertise.
The Specific Aims of the Core are to:1. Provide aerosol challenge systems suitable for exposing mice, rats, guinea pigs, or rabbits toaerosols composed of live bacteria, lipopolysaccharide, antigenic proteins, or immunomodulators.2. Provide investigators with specimens harvested at specific time points after aerosol challenge topermit study of bacterial and host responses to the infection or inflammatory stimulus.3. Provide histopathologic and multiplex protein analyses of tissue specimens harvested in theseexperiments and in other studies performed by RCE investigators, to facilitate investigation ofinflammatory and immune responses in the lungs.
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