Abstract

The Admin Core ofthe GLRCE is led by its Director, Dr. Olaf Schneewind and Associate Director, Dr. Bill Blaylock. The Core is designed to support and guarantee the financial and administrative integrity ofthe GLRCE. We strive to guide all affiliated projects to paths that will achieve the scientific and translational goals ofthe GLRCE. We accomplish this by providing scientifically objective and even-handed direcfion and coordination ofthe projects. The Admin Core will identify new opportunities, attract intellectual and infrastructural resources, as well as maintain our open and flexible environment which enables us to respond quickly to new developments within and outside of Region V. The organization of the core links investigators with pharmaceutical and biotech companies as well as federal, state and local agencies to foster translational research and promote maximal use of the facilities, as well as research and promote other networking opportunifies to foster ongoing and mutually beneficial relationships in the scientific community.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI057153-10
Application #
8448675
Study Section
Special Emphasis Panel (ZAI1-DDS-M)
Project Start
2013-03-01
Project End
2014-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
10
Fiscal Year
2013
Total Cost
$450,196
Indirect Cost
$125,194

  Institution

Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Hoang, Ky V; Rajaram, Murugesan V S; Curry, Heather Marie et al. (2018) Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes. Front Immunol 9:561
Mitchell, Anthony; Tam, Christina; Elli, Derek et al. (2017) Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis. MBio 8:
Chen, Grischa Y; McDougal, Courtney E; D'Antonio, Marc A et al. (2017) A Genetic Screen Reveals that Synthesis of 1,4-Dihydroxy-2-Naphthoate (DHNA), but Not Full-Length Menaquinone, Is Required for Listeria monocytogenes Cytosolic Survival. MBio 8:
Sloup, Rudolph E; Konal, Ashley E; Severin, Geoffrey B et al. (2017) Cyclic Di-GMP and VpsR Induce the Expression of Type II Secretion in Vibrio cholerae. J Bacteriol 199:
Kant, Sashi; Asthana, Shailendra; Missiakas, Dominique et al. (2017) A novel STK1-targeted small-molecule as an ""antibiotic resistance breaker"" against multidrug-resistant Staphylococcus aureus. Sci Rep 7:5067
Coulson, Garry B; Johnson, Benjamin K; Zheng, Huiqing et al. (2017) Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics. Cell Chem Biol 24:993-1004.e4
Hollands, Andrew; Corriden, Ross; Gysler, Gabriela et al. (2016) Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem 291:13964-73
Kuhn, Misty L; Alexander, Evan; Minasov, George et al. (2016) Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis. ACS Infect Dis 2:579-591
Duckworth, Benjamin P; Wilson, Daniel J; Aldrich, Courtney C (2016) Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay. Methods Mol Biol 1401:53-61
Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng et al. (2016) Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nat Commun 7:10710

Showing the most recent 10 out of 516 publications