The programs of the SERCEB have immediate and projected requirements for monoclonalantibodies (mAbs) for studies of pathogenesis, immune response, vaccine development,therapeutics and diagnostics. These reagents and bio-recognition elements will be vital to thesuccess of proposed research projects. The nature and source of the monoclonal antibodiesrequired will depend on the objective of the research program, ranging from murine monoclonalantibodies for immunohistochemistry and detection to human or humanized mouse antibodiesfor development of therapeutics. Broad expertise exists within the institutions of the SERCEBin mAb development, testing and use. The spectrum of expertise in mAb development includeshuman, mouse, humanized mouse, rhesus, and phage display human and mouse F abs andScFv. Finally, the antibodies will be deliverables that may have immediate application intherapeutics and diagnostics. The proposed Core C is a distributed core that uses establishedlabs at several institutions to provide each of the needed services. The Core will provide all ofthe biorecognition elements needed in the SERCEB and will develop them into new assays andbiosensors.The core has four Specific Aims.
Aim 1. Generate human mAbs to poxvirus neutralization targets and anthrax protectiveantigen.
Aim 2. Generate high-quality mAb reagents for SERCEB research programs.
Aim 3. Develop biosensors for diagnostics or detection of select agents using novel mAbsavailable in the SERCEBAim 4. To develop a database and repository for mAbs within the SERCEB that can beshared across institutions, to facilitate the other scientific programs.
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