The Developmental Projects Program funds early-stage research projects with the potential to develop into more substantial research programs. Its objective is to promote innovative research in areas that can translate into the development of new vaccines, therapeutics and/or diagnostics to combat Category A-C select agents or other emerging infectious pathogens. The Developmental Projects Program invests in initiatives having the greatest potential to compete for traditional National Institutes of Health (NIH) funding Project support will be provided for up to 24 months, with an annual budget between $100,000 and $125,000 in direct costs. The intent is to fund """"""""higher-risk"""""""" research, requiring less preliminary data than a conventional R01 grant. The Program also seeks to attract Region II investigators with novel approaches, who may not presently be working in the area of biodefense. The Developmental Projects Program encourages collaborations among investigators involved in basic and clinical microbiology research and others in immunology, cell biology, chemical biology, and bioinformatics. To create the most fertile environment for discovery, strategic investments will be directed to novel projects with the potential for high return and a good probability of qualifying for future NIH funding.

Public Health Relevance

The developmental projects program will increase the scope and range of research, investigators and institutions involved in the RCE Program in Region 2 allowing for the development of new technologies, vaccines, diagnostics and therapeutics in the areas of biodefense and emerging infectious diseases

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI057158-07
Application #
8043563
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2010-03-01
Budget End
2011-02-28
Support Year
7
Fiscal Year
2010
Total Cost
$776,889
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Li, Xiao-Ping; Kahn, Jennifer N; Tumer, Nilgun E (2018) Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding. Toxins (Basel) 10:
Goldman, David L; Nieves, Edward; Nakouzi, Antonio et al. (2018) Serum-Mediated Cleavage of Bacillus anthracis Protective Antigen Is a Two-Step Process That Involves a Serum Carboxypeptidase. mSphere 3:
Marié, Isabelle J; Chang, Hao-Ming; Levy, David E (2018) HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies. J Exp Med 215:3194-3212
Uhde, Melanie; Ajamian, Mary; Wormser, Gary P et al. (2017) Reply to Naktin. Clin Infect Dis 64:1145-1146
Chen, Han; Coseno, Molly; Ficarro, Scott B et al. (2017) A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis 3:112-118
Aguilar, Jorge L; Varshney, Avanish K; Pechuan, Ximo et al. (2017) Monoclonal antibodies protect from Staphylococcal Enterotoxin K (SEK) induced toxic shock and sepsis by USA300 Staphylococcus aureus. Virulence 8:741-750
Zhou, Yijun; Li, Xiao-Ping; Chen, Brian Y et al. (2017) Ricin uses arginine 235 as an anchor residue to bind to P-proteins of the ribosomal stalk. Sci Rep 7:42912
Taylor, Travis J; Diaz, Fernando; Colgrove, Robert C et al. (2016) Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector. Virology 496:186-193
Steyer, Andrej; Jevšnik, Monika; Petrovec, Miroslav et al. (2016) Narrowing of the Diagnostic Gap of Acute Gastroenteritis in Children 0-6 Years of Age Using a Combination of Classical and Molecular Techniques, Delivers Challenges in Syndromic Approach Diagnostics. Pediatr Infect Dis J 35:e262-70
Song, Jeongmin; Wilhelm, Cara L; Wangdi, Tamding et al. (2016) Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Cell 164:827-8

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