There continues to be a paucity of researchers conducting basic, clinical, and translational research on priority pathogens and the methods to prevent and treat infections by these agents. The Career Development in Biodefense program of the of the New England Regional Center for Excellence for Biodefense and Emerging Diseases is designed to increase the pool of highly skilled investigators in all aspects of research on priority pathogens. This Career Development program will integrate educational and training efforts in priority pathogens from both the basic science and the clinical aspects. The objectives of this program are to recruit investigators at early stages in their careers into work on priority pathogens through training in basic science and clinical/translational research and to provide opportunities for continuing education for all investigators in priority pathogen research throughout the New England region. We propose a combination of individual programs and group programs. The central component of the individual programs we propose is an Early Career Development Program for Recruitment into Research on Priority Pathogens. The focus of this career development program is to identify and support individuals early on in their training and recruit them into careers relevant to research on priority pathogens. Training in this program spans the broad range of basic laboratory-based research, clinical investigation in human subjects, and translational research. Awards will fund applicants to conduct a research training program relevant to priority pathogens of 2 or 3 years in duration, which will prepare them for more independent research or to be successful applicants for additional career development research awards from the NIH. To complement the individual programs, we propose group educational opportunities designed to promote continuing education of the New England biomedical scientific community in areas of priority pathogen research. The group programs we propose fall into three areas: (1) an annual scientific retreat;(2) a seminar series;and (3) workshops on topics of relevance to New England investigators conducting research on priority pathogens.

Public Health Relevance

There continues to be a shortage of researchers conducting research on priority pathogens and the methods to prevent and treat infections by these agents. Our program will (1) identify individuals early on in their training and recruit them into careers relevant to priority pathogens, and (2) provide continuing education opportunities for the New England biomedical scientific community in areas of priority pathogen research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI057159-07
Application #
8038353
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2010-03-01
Budget End
2011-02-28
Support Year
7
Fiscal Year
2010
Total Cost
$589,140
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
de Wispelaere, Melissanne; Lian, Wenlong; Potisopon, Supanee et al. (2018) Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chem Biol 25:1006-1016.e8
Huang, Nai-Jia; Pishesha, Novalia; Mukherjee, Jean et al. (2017) Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin. Nat Commun 8:423
Mertins, Philipp; Przybylski, Dariusz; Yosef, Nir et al. (2017) An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Rep 19:2853-2866
Nair, Dhanalakshmi R; Chen, Ji; Monteiro, João M et al. (2017) A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism. J Antibiot (Tokyo) 70:1009-1019
Choo, Min-Kyung; Sano, Yasuyo; Kim, Changhoon et al. (2017) TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med 214:1297-1311
de Wispelaere, Mélissanne; Carocci, Margot; Liang, Yanke et al. (2017) Discovery of host-targeted covalent inhibitors of dengue virus. Antiviral Res 139:171-179
Umetsu, Dale T (2017) Mechanisms by which obesity impacts upon asthma. Thorax 72:174-177
Zheng, Huiqing; Colvin, Christopher J; Johnson, Benjamin K et al. (2017) Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol 13:218-225
Coulson, Garry B; Johnson, Benjamin K; Zheng, Huiqing et al. (2017) Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics. Cell Chem Biol 24:993-1004.e4
Moayeri, Mahtab; Tremblay, Jacqueline M; Debatis, Michelle et al. (2016) Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice. Clin Vaccine Immunol 23:213-8

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