Specific Aim:
The specific aim of this career development project is to provide advanced training for health professionals to assume a leadership role in biodefense and emerging infectious disease clinical research. Facilitation of communication and collaborations between clinical and basic scientists, development of understanding of public health practice and policy, and establishment of connections to facilitate the translational research of the RCE basic scientists, especially in development and trials of diagnostics, vaccines and therapeutics. Objectives, design and methods: A clinical/translational sciences research career development program will be established at Colorado State University Veterinary,Diagnostic Laboratory (CSU-VDL). The clinical training program will accept one new trainee every other year. The goal will be to provide structure for advanced training for veterinarians who wish to assume leadership roles in biodefense and emerging infectious disease clinical and translational sciences research. Within the overall RCE, the faculty and trainees in the clinical career development project will play a critical role in facilitating interactions and collaborations between clinical and basic scientists, developing an understanding of agriculture and public health practice and policy, and establishing connections to facilitate the translational research of the RCE basic scientists, especially in relation to the development of diagnostics, vaccines and therapeutics. To provide meaningful accredited training within the auspices of the RCE program, career development trainees will be required to participate in the core activities such as training in research ethics and the basic methods, rules and regulations for safe handling of NIH pathogens and CDC select agents. Clinical/translational career development trainees will present various credentials upon entry into the program, will pursue varied goals, and will finish with different outcomes. The following is an example for a possible program for a trainee in the clinical/translational career development program in for veterinarians. DVM with two-years residency training in infectious diseases -? Accepted into RCE clinical/translational research program -? Completes two years with RCE clinical/translational research program, publishes manuscripts -> Obtains further funding with NIH K08 to complete research project -? Is recruited to academic, government, or industry position

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI065357-03
Application #
7450999
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
3
Fiscal Year
2007
Total Cost
$177,393
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Type
DUNS #
785979618
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
Webb, Jessica R; Price, Erin P; Somprasong, Nawarat et al. (2018) Development and validation of a triplex quantitative real-time PCR assay to detect efflux pump-mediated antibiotic resistance in Burkholderia pseudomallei. Future Microbiol 13:1403-1418
York, Joanne; Nunberg, Jack H (2018) A Cell-Cell Fusion Assay to Assess Arenavirus Envelope Glycoprotein Membrane-Fusion Activity. Methods Mol Biol 1604:157-167
Rhodes, Katherine A; Somprasong, Nawarat; Podnecky, Nicole L et al. (2018) Molecular determinants of Burkholderia pseudomallei BpeEF-OprC efflux pump expression. Microbiology 164:1156-1167
Cummings, Jason E; Slayden, Richard A (2017) Transient In Vivo Resistance Mechanisms of Burkholderia pseudomallei to Ceftazidime and Molecular Markers for Monitoring Treatment Response. PLoS Negl Trop Dis 11:e0005209
Pettey, W B P; Carter, M E; Toth, D J A et al. (2017) Constructing Ebola transmission chains from West Africa and estimating model parameters using internet sources. Epidemiol Infect 145:1993-2002
Furuta, Yousuke; Komeno, Takashi; Nakamura, Takaaki (2017) Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase. Proc Jpn Acad Ser B Phys Biol Sci 93:449-463
Skyberg, Jerod A; Lacey, Carolyn A (2017) Hematopoietic MyD88 and IL-18 are essential for IFN-?-dependent restriction of type A Francisella tularensis infection. J Leukoc Biol 102:1441-1450
Plumley, Brooke A; Martin, Kevin H; Borlee, Grace I et al. (2017) Thermoregulation of Biofilm Formation in Burkholderia pseudomallei Is Disrupted by Mutation of a Putative Diguanylate Cyclase. J Bacteriol 199:
Randall, Linnell B; Georgi, Enrico; Genzel, Gelimer H et al. (2017) Finafloxacin overcomes Burkholderia pseudomallei efflux-mediated fluoroquinolone resistance. J Antimicrob Chemother 72:1258-1260
Podnecky, Nicole L; Rhodes, Katherine A; Mima, Takehiko et al. (2017) Mechanisms of Resistance to Folate Pathway Inhibitors in Burkholderia pseudomallei: Deviation from the Norm. MBio 8:

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