The goal of this proposal is to support a state-of-the-art """"""""small animal imaging research program for Infectious disease"""""""" (SAIRPID) at the Saban Research Institute/CHLA as a shared resource (core facility) for the community of scientists. The SAIRPID at Saban Research Institute will generously support this effort by allocating space and assisting in the acquisition of imaging instruments, which include, a Bruker 7 Tesla Pharmascan MR system, an ImTek microCT system, Xenogen multiview bioluminescent/fluorescence imaging system, indigenously developed optical imaging system, Faxitron high resolution x-ray system, Siemens gamma camera, Acuson real-time/Doppler ultrasound and a Gamma-Medica microCT/SPECT system. These instruments are housed in a new 12,000 sq ft facility within the vivarium of the Saban Research Institute at CHLA. This imaging facility is designed to handle animals both within the institute and from external sources by having a separate quarantine room with sterile pass box into the imaging facility. The small animal imaging program already has established a track record of successful collaborations with industry partners (ImTek, Novartis, Continuum Lasers Inc.), and investigators at outside institutions such as Cal Tech, Navel Research Labs at NPS, Monterey, Cedar Sinai Hospital at Los Angeles, UCI: Beckman Laser Institute, the USC School of Medicine and the School of Dentistry, the City of Hope, UCLA, and University of Madrid, Spain. The objectives of this proposal are: I). To support a state-of-the-art small animal imaging research program for Infectious disease (SAIRPID) at Saban Research Institute as a shared resource for the community of scientists. 2). Develop new imaging technology in fluorescence and near infrared optical imaging in small animal models, promoting intra-mural as well as inter-mural collaboration. Under intra-mural collaboration, the research will be directed at the development ofnon invasive , in-vivo optical imaging techniques and the development of new agents that have imaging labels built into the initial design for the diagnosis of priority pathogens like Junin virus and Listeria monocytogenes etc. 3). Provide opportunities for women, minority and young investigators to use these facilities through collaboration with relevant personnel and pilot studies. 4). Establish a training program and seminar series in small animal imaging. By expanding the capabilities of this program, we hope to provide more investigators access to these exciting new small animal imaging technologies in an effort to foster interdisciplinary research in the fight against bio-terrorism.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Irvine
United States
Zip Code
Tsai, Wen-Yang; Youn, Han Ha; Tyson, Jasmine et al. (2018) Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections. Emerg Infect Dis 24:1355-1359
Thongsripong, Panpim; Chandler, James Angus; Green, Amy B et al. (2018) Mosquito vector-associated microbiota: Metabarcoding bacteria and eukaryotic symbionts across habitat types in Thailand endemic for dengue and other arthropod-borne diseases. Ecol Evol 8:1352-1368
Katzelnick, Leah C; Ben-Shachar, Rotem; Mercado, Juan Carlos et al. (2018) Dynamics and determinants of the force of infection of dengue virus from 1994 to 2015 in Managua, Nicaragua. Proc Natl Acad Sci U S A 115:10762-10767
Clemens, Daniel L; Lee, Bai-Yu; Horwitz, Marcus A (2018) The Francisella Type VI Secretion System. Front Cell Infect Microbiol 8:121
Nualnoi, Teerapat; Norris, Michael H; Tuanyok, Apichai et al. (2017) Development of Immunoassays for Burkholderia pseudomallei Typical and Atypical Lipopolysaccharide Strain Typing. Am J Trop Med Hyg 96:358-367
Parameswaran, Poornima; Wang, Chunling; Trivedi, Surbhi Bharat et al. (2017) Intrahost Selection Pressures Drive Rapid Dengue Virus Microevolution in Acute Human Infections. Cell Host Microbe 22:400-410.e5
Bortell, Nikki; Flynn, Claudia; Conti, Bruno et al. (2017) Osteopontin Impacts West Nile virus Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points. Mediators Inflamm 2017:7582437
Hertz, Tomer; Beatty, P Robert; MacMillen, Zachary et al. (2017) Antibody Epitopes Identified in Critical Regions of Dengue Virus Nonstructural 1 Protein in Mouse Vaccination and Natural Human Infections. J Immunol 198:4025-4035
Barbour, Alan G (2017) Infection resistance and tolerance in Peromyscus spp., natural reservoirs of microbes that are virulent for humans. Semin Cell Dev Biol 61:115-122
Huwyler, Camille; Heiniger, Nadja; Chomel, Bruno B et al. (2017) Dynamics of Co-Infection with Bartonella henselae Genotypes I and II in Naturally Infected Cats: Implications for Feline Vaccine Development. Microb Ecol 74:474-484

Showing the most recent 10 out of 467 publications