This application aims to facilitate research on eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), and eosinophilic colitis (EC) through the development of a Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). CEGIR comprises clinical centers in Ohio (the coordinating center), Colorado, California, Indiana, Pennsylvania, Illinois, North Carolina, Massachusetts, Switzerland, and Maryland. All participating domestic, non-National Institutes of Health (NIH) clinical centers are associated with a Clinical Translational Science Award (CTSA). The CEGIR sites have been carefully chosen on the basis of their preexisting record of collaboration with each other;diverse expertise in relevant clinical specialties including Gastroenterology, Allergy, Immunology, and Pathology;the ability to integrate pediatric and adult patients into a common consortium;and well-established record of excellence in clinical research involving this patient population. Importantly, the CEGIR sites have proven access to an adequate number of patients with the rare diseases studied, as evidenced from the recent completion of the first set of controlled clinical trials involving this patient population. Strong patient advocacy groups (PAGs), including the American Partnership for Eosinophilic Disorders (APFED) and the Campaign Urging Research for Eosinophilic Disease (CURED), already partner with the CEGIR Investigators and will continue to work synergistically in the context of CEGIR. Despite the recent record of advances by CEGIR Investigators, the early success of their collaborative interactions, the proactive PAGs, and the development of novel anti-eosinophil therapeutics, there is no currently existing funding for a clinical network focusing on these three rare, distinct diseases, highlightig the timeliness and importance of this application.
Eosinophilic esophagitis, eosinophilic gastritis, and eosinophilic colitis are painful, lifelong diseases that make it difficult or impossible for indiviuals to eat many or all foods. Individuals with these diseases often have to fuel their bodies by drinking costly formulas. We will partner with researchers, patients, and other key groups, including patient advocacy groups, to better understand, treat, and educate about these diseases.
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| Naramore, Sara; Gupta, Sandeep K (2018) Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions. J Pediatr Gastroenterol Nutr 67:318-321 |
| Hill, David A; Spergel, Jonathan M (2018) Is eosinophilic esophagitis a member of the atopic march? Ann Allergy Asthma Immunol 120:113-114 |
| Spergel, Jonathan; Aceves, Seema S (2018) Allergic components of eosinophilic esophagitis. J Allergy Clin Immunol 142:1-8 |
| Wechsler, Joshua B; Hirano, Ikuo (2018) Biological therapies for eosinophilic gastrointestinal diseases. J Allergy Clin Immunol 142:24-31.e2 |
| Spergel, Jonathan M; Dellon, Evan S; Liacouras, Chris A et al. (2018) Summary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conference. Ann Allergy Asthma Immunol 121:281-284 |
| Shoda, Tetsuo; Wen, Ting; Aceves, Seema S et al. (2018) Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study. Lancet Gastroenterol Hepatol 3:477-488 |
| O'Shea, Kelly M; Aceves, Seema S; Dellon, Evan S et al. (2018) Pathophysiology of Eosinophilic Esophagitis. Gastroenterology 154:333-345 |
| Wang, Ryan; Hirano, Ikuo; Doerfler, Bethany et al. (2018) Assessing Adherence and Barriers to Long-Term Elimination Diet Therapy in Adults with Eosinophilic Esophagitis. Dig Dis Sci 63:1756-1762 |
| Hill, David A; Spergel, Jonathan M (2018) The atopic march: Critical evidence and clinical relevance. Ann Allergy Asthma Immunol 120:131-137 |
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