Data Science Research: The Big Data revolution requires that biomedical scientists be able to locate, analyze, and integrate the large datasets that now pervade biomedicine. Such work is possible only when experimental datasets are made available online and when they are annotated with metadata that explain how the data are organized, what the data represent, and how the data were collected. The Center for Expanded Data Annotation and Retrieval (CEDAR) will take advantage ofthe recent growth in communitydriven metadata standards to develop innovative computational methods to ease the authoring and use of metadata annotations.
Our specific aims focus on working with communities of investigators to standardize descriptions of the data generated through biomedical studies; creating a computational collective for development, evaluation, use, and refinement of metadata templates for describing laboratory studies; developing a comprehensive and open repository of metadata that will inform the learning algorithms that will drive much of our Center's technology; training the biomedical community in the use of metadata and in CEDAR's resources; and evaluating our work in the context of ImmPort, an NIAID-supported multi-assay data repository that will offer end-to-end opportunities to demonstrate and validate our ideas. We anticipate a growing community of users, starting with the Human Immunology Project Consortium, then the BD2K Center Consortium, then the Stanford Digital Repository, growing until we have developed a wide user base leading to measurable changes in the quality of the metadata used to annotate online datasets. The Data Science Research component of our Center will study methods to build metadata templates and computational services to accelerate and facilitate the annotation of experimental data with metadata. We will create a repository of metadata from which to learn patterns to inform the metadata-authoring process and make it possible to query across data repositories reliably, thereby enabling the integration of a wealth of online data sets.

Public Health Relevance

The ability to locate, analyze, and integrate Big Data depends on the metadata that describe data sets and the experiments that have been performed. This project will facilitate annotation of data with high quality metadata. The results of our work will lead to better data and, thus, to better science. Ultimately, such results will lead to better health.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZRG1)
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Stanford University
United States
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Bukhari, Syed Ahmad Chan; Martínez-Romero, Marcos; O' Connor, Martin J et al. (2018) CEDAR OnDemand: a browser extension to generate ontology-based scientific metadata. BMC Bioinformatics 19:268
Sweeney, Timothy E; Azad, Tej D; Donato, Michele et al. (2018) Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters. Crit Care Med 46:915-925
Sweeney, Timothy E; Wynn, James L; Cernada, María et al. (2018) Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis. J Pediatric Infect Dis Soc 7:129-135
Bukhari, Syed Ahmad Chan; O'Connor, Martin J; Martínez-Romero, Marcos et al. (2018) The CAIRR Pipeline for Submitting Standards-Compliant B and T Cell Receptor Repertoire Sequencing Studies to the National Center for Biotechnology Information Repositories. Front Immunol 9:1877
Panahiazar, Maryam; Dumontier, Michel; Gevaert, Olivier (2017) Predicting biomedical metadata in CEDAR: A study of Gene Expression Omnibus (GEO). J Biomed Inform 72:132-139
Martínez-Romero, Marcos; O'Connor, Martin J; Shankar, Ravi D et al. (2017) Fast and Accurate Metadata Authoring Using Ontology-Based Recommendations. AMIA Annu Symp Proc 2017:1272-1281
Raymond, Steven L; López, María Cecilia; Baker, Henry V et al. (2017) Unique transcriptomic response to sepsis is observed among patients of different age groups. PLoS One 12:e0184159
Sweeney, Timothy E; Khatri, Purvesh (2017) The authors reply. Crit Care Med 45:e457-e458
Martínez-Romero, Marcos; Jonquet, Clement; O'Connor, Martin J et al. (2017) NCBO Ontology Recommender 2.0: an enhanced approach for biomedical ontology recommendation. J Biomed Semantics 8:21
Sweeney, Timothy E; Khatri, Purvesh (2017) Septic Cardiomyopathy: Getting to the Heart of the Matter. Crit Care Med 45:556-557

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