(BBDC Administrative Core) The BBDC administrative core will coordinate and implement the BBDC under the direction of the overall PI Dr. Brendan Lee, co-PI Tracy Hart, and Clinical Team Liaison Dr. V. Reid Sutton. It will also coordinate the interactions among the clinical sites, cores, and the patient advocacy site. To achieve this, the Core will track and facilitate funds transfer and subcontracts between participating sites, schedule and prepare agendas for monthly teleconferences separately for the executive committee, the PI-steering committee, and site coordinators. The Core will coordinate the annual BBDC in person meeting in conjunction with the annual Osteogenesis Imperfecta Foundation Scientific Meeting, and facilitate the annual Geisman training fellowship competition. Finally, the core will administer and review a) clinical training fellowships by the OIF, b) pilot project applications, c) requests for access to bio-specimens collected within the longitudinal study, d) centralized radiographic reading and quality/assessment of imaging sites, and coordinate e) the annual external advisory committee review and f) administrative preparation of documents for single Institutional Review Board (sIRB) and Data and Safety Monitoring Board (DSMB) review. The Core will be responsible for all communications between the BBDC and the broader RDCRN and Participant communities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AR068069-07
Application #
10017032
Study Section
Special Emphasis Panel (ZTR1)
Project Start
2014-08-06
Project End
2024-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
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Dagdeviren, Didem; Tamimi, Faleh; Lee, Brendan et al. (2018) Dental and craniofacial characteristics caused by the p.Ser40Leu mutation in IFITM5. Am J Med Genet A :
Jain, Mahim; Tam, Allison; Shapiro, Jay R et al. (2018) Growth characteristics in individuals with osteogenesis imperfecta in North America: results from a multicenter study. Genet Med :
Najirad, Mohammadamin; Ma, Mang Shin; Rauch, Frank et al. (2018) Oral health-related quality of life in children and adolescents with osteogenesis imperfecta: cross-sectional study. Orphanet J Rare Dis 13:187
Tam, Allison; Chen, Shan; Schauer, Evan et al. (2018) A multicenter study to evaluate pulmonary function in osteogenesis imperfecta. Clin Genet 94:502-511
Lim, Joohyun; Grafe, Ingo; Alexander, Stefanie et al. (2017) Genetic causes and mechanisms of Osteogenesis Imperfecta. Bone 102:40-49
Lietman, Caressa D; Lim, Joohyun; Grafe, Ingo et al. (2017) Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone. J Bone Miner Res 32:1354-1367
Grafe, Ingo; Alexander, Stefanie; Yang, Tao et al. (2016) Sclerostin Antibody Treatment Improves the Bone Phenotype of Crtap(-/-) Mice, a Model of Recessive Osteogenesis Imperfecta. J Bone Miner Res 31:1030-40
Bellur, S; Jain, M; Cuthbertson, D et al. (2016) Cesarean delivery is not associated with decreased at-birth fracture rates in osteogenesis imperfecta. Genet Med 18:570-6
Lietman, Caressa D; Marom, Ronit; Munivez, Elda et al. (2015) A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation. J Bone Miner Res 30:489-98