Abstract

The Biostatistics Core will support the clinical and laboratory-based projects of this grant so that research studies research studies are efficiently designed, conducted, monitored and analyzed. Activities will include formalization of hypotheses to be tested to ensure that valid conclusions can be drawn, design of clinical trials and laboratory studies, database development, data management, and data analysis. The Biostatistics Core will provide input into the statistical aspects of the projects, including experimental design and development, and validation of novel measurements, and will provide innovative and modern statistical analysis of the data. The objective is to provide statistical support as required by the projects and cores to achieve their specific aims. The statistical components of all clinical and laboratory protocols will include determination of the type of design to be used, calculation of number of experimental units (animals or patients) needed, assessment of the types of data to be collected for each study, specification of design parameters such as sample size, type I and type II error rates of tests of hypotheses, and provision for interim analyses when appropriate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA090810-01
Application #
6481699
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2001-07-16
Project End
2005-12-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Wang, Ruoning; Jung, Sung Yun; Wu, Chuan Fen et al. (2010) Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation. Proc Natl Acad Sci U S A 107:19885-90
Kopetz, Scott; Hoff, Paulo M; Morris, Jeffrey S et al. (2010) Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol 28:453-9
Connelly, Sarah F; Isley, Beth A; Baker, Cheryl H et al. (2010) Loss of tyrosine phosphatase-dependent inhibition promotes activation of tyrosine kinase c-Src in detached pancreatic cells. Mol Carcinog 49:1007-21
Trepel, Martin; Stoneham, Charlotte A; Eleftherohorinou, Hariklia et al. (2009) A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer. Mol Cancer Ther 8:2383-91
Ng, Chaan S; Kodama, Yoshihisa; Mullani, Nizar A et al. (2009) Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study. J Comput Assist Tomogr 33:460-5
Wang, Wei; Shao, Ruping; Wu, Qingping et al. (2009) Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide. Mol Imaging Biol 11:424-33
Kim, M P; Park, S I; Kopetz, S et al. (2009) Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis. Cell Tissue Res 335:249-59
Kopetz, Scott; Lesslie, Donald P; Dallas, Nikolas A et al. (2009) Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress. Cancer Res 69:3842-9
Nie, Jing; Chang, Benny; Traktuev, Dmitry O et al. (2008) IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells. Stem Cells 26:2735-45
Urbanczyk-Pearson, Lauren M; Femia, Frank J; Smith, Jeffrey et al. (2008) Mechanistic investigation of beta-galactosidase-activated MR contrast agents. Inorg Chem 47:56-68

Showing the most recent 10 out of 84 publications