Abstract

The Statistical Core plays a central role in the functioning of the Immunologic Monitoring Consortium (IMC). Statistical collaboration is required in assay development, comparison, and in the design and execution of the clinical trials that will serve to validate the ability of developed assays to monitor immune responses. The statistical core will work with the administrative core to develop the website to be used as a data repository and will work with each project to perform all the analyses at the pre-clinical and clinical levels. The specific functions of the statistical core are to: (1) assess the reproducibility of the methodologies developed in the four projects and to estimate properties of assay results in volunteers and in cancer patients, (2) assess immune augmentation after immunization, (3) assess the degree of agreement among the four assays, ( 4) provide design and analysis of immunization studies in animals to assess correlation of immune response with anti-tumor activity, and, (5) provide design and analysis of clinical trials of vaccines in cancer patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA090818-02
Application #
6563978
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-02-19
Project End
2002-12-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
2002
Total Cost
$296,752
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Slota, Meredith; Lim, Jong-Baeck; Dang, Yushe et al. (2011) ELISpot for measuring human immune responses to vaccines. Expert Rev Vaccines 10:299-306
Coveler, Andrew L; Goodell, Vivian; Webster, Devon J et al. (2009) Common adjuvant breast cancer therapies do not inhibit cancer vaccine induced T cell immunity. Breast Cancer Res Treat 113:95-100
Maecker, Holden T (2009) Multiparameter flow cytometry monitoring of T cell responses. Methods Mol Biol 485:375-91
Ladd, Jon; Lu, Hailing; Taylor, Allen D et al. (2009) Direct detection of carcinoembryonic antigen autoantibodies in clinical human serum samples using a surface plasmon resonance sensor. Colloids Surf B Biointerfaces 70:1-6
Maecker, Holden T; Hassler, Jeffrey; Payne, Janice K et al. (2008) Precision and linearity targets for validation of an IFNgamma ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides. BMC Immunol 9:9
Goodell, Vivian; Waisman, James; Salazar, Lupe G et al. (2008) Level of HER-2/neu protein expression in breast cancer may affect the development of endogenous HER-2/neu-specific immunity. Mol Cancer Ther 7:449-54
Park, Kyong Hwa; Gad, Ekram; Goodell, Vivian et al. (2008) Insulin-like growth factor-binding protein-2 is a target for the immunomodulation of breast cancer. Cancer Res 68:8400-9
Goodell, Vivian; McNeel, Douglas; Disis, Mary L (2008) His-tag ELISA for the detection of humoral tumor-specific immunity. BMC Immunol 9:23
Siebert, Janet C; Inokuma, Margaret; Waid, Dan M et al. (2008) An analytical workflow for investigating cytokine profiles. Cytometry A 73:289-98
Goodell, Vivian; dela Rosa, Corazon; Slota, Meredith et al. (2007) Sensitivity and specificity of tritiated thymidine incorporation and ELISPOT assays in identifying antigen specific T cell immune responses. BMC Immunol 8:21

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