Strong ties have developed between cancer researchers at Meharry Medical College (MMC) and the Vanderbilt-lngram Comprehensive Cancer Center (VICC) over the past five years of their formal partnership. The bedrock of this pioneering collaboration has been the U54 from the NCI. Our partnership is dedicated to enhancing the strengths and eliminating the weaknesses of our two institutions as we move toward our shared goal of eliminating cancer disparities in the US. The U54 award has moved our collaborative research program more forcefully toward a relationship that is based on reciprocity and stronger mutual benefit. Until recently, MMC viewed itself primarily as a teaching institution and, therefore, did not have a critical mass of researchers in cancer. MMC, with pivotal help from U54 funds, is growing its capacity but has a thriving concentration of cancer researchers in cancer biology, cancer epidemiology and clinical cancer research. The U54 has provided the major impetus for a bold restructuring of the basic science departments at MMC that will assure release time for MMC investigators. The Division of Cancer Biology, headed by Dr. Adunyah, Co-Pi of the U54 at MMC will consist of faculty with 80% release time for research. In cooperation with the U54 Pis, mentoring committees consisting of faculty from MMC and VICC will assist faculty in developing competitive research programs. This restructure was due, in part, to recommendations made by our Program Steering Committee at their 2003 and 2004 meetings. Funds provided by this U54 will solidify our collaboration. During this second phase of our partnership, we concentrate on amassing sufficient infrastructure for cancer research that will strengthen reciprocity between MMC and VICC. In addition to funding research studies, funds will be used to recruit investigators and strengthen infrastructure in basic, epidemiologic and clinical cancer research at MMC. A critical mass of researchers in all these areas will strengthen the quality of MMC/VICC collaborative efforts. A sustained and comprehensive Cancer Partnership between MMC and VICC is of immense benefit to the two participating institutions as well as the mid-South region of the US. Our major collaborative successes including the Southern Community Cohort Study of urban and rural African Americans and Caucasians in the mid-South testify to our potential for meeting our goal of eliminating cancer disparities between African Americans and Caucasians.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA091405-09
Application #
7666771
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (O1))
Program Officer
Aguila, H Nelson
Project Start
2001-07-16
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
9
Fiscal Year
2009
Total Cost
$795,807
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Nichols, Erin E; Richmond, Ann; Daniels, Anthony B (2016) Tumor Characteristics, Genetics, Management, and the Risk of Metastasis in Uveal Melanoma. Semin Ophthalmol 31:304-9
Vaiopoulou, Anna; Gazouli, Maria; Papadopoulou, Aggeliki et al. (2015) Serum protein profiling of adults and children with Crohn disease. J Pediatr Gastroenterol Nutr 60:42-7
Ning, Matthew S; Kim, Annette S; Prasad, Nripesh et al. (2014) Characterization of the Merkel Cell Carcinoma miRNome. J Skin Cancer 2014:289548
Seeley, Erin H; Washington, Mary K; Caprioli, Richard M et al. (2013) Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl 7:541-9
M'Koma, Amosy E (2013) Letter to Editor. Adv Enzyme Res 1:77-78
Ochieng, Josiah; Chaudhuri, Gautam (2010) Cystatin superfamily. J Health Care Poor Underserved 21:51-70
Mittal, Mukul K; Myers, Jeremy N; Bailey, Charvann K et al. (2010) Mode of action of the retrogene product SNAI1P, a SNAIL homolog, in human breast cancer cells. Mol Biol Rep 37:1221-7
Zheng, Wei; Cai, Qiuyin; Signorello, Lisa B et al. (2009) Evaluation of 11 breast cancer susceptibility loci in African-American women. Cancer Epidemiol Biomarkers Prev 18:2761-4
Daikoku, Takiko; Hirota, Yasushi; Tranguch, Susanne et al. (2008) Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res 68:5619-27
Daikoku, Takiko; Tranguch, Susanne; Chakrabarty, Anindita et al. (2007) Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res 67:5285-92

Showing the most recent 10 out of 11 publications