The regions served by the Howard University Cancer Center (HUCC) and Johns Hopkins Comprehensive Cancer Center (JHCCC), Maryland and the District of Columbia, have had among the highest cancer death rates in the United States for more than fifty years. Minority residents of these regions have been disproportionately affected by cancer, and cancer has become a leading cause of morbidity and mortality for African-Americans in both Baltimore, Maryland, and Washington, D.C. To address this problem, HUCC and JHCCC have embarked on a partnership to increase productive research in screening diagnosis, prevention, treatment, and supportive care as it relates to cancer, with a special focus on cancer in African-Americans. The HUCC/JHCCC partnership, which began as a series of collaborative efforts involving faculty from each institution organized into groups targeting high priority areas, has been supported since September of 1999 by supplemental funds for the JHCCC core grant from the National Cancer Institute (NCI). The success realized thus far during the planning phases of the HUCC/JHCCC partnership, with c9ollaborative research progress in several areas, including prostate cancer, gastrointestinal cancer, and breast cancer, has prompted the submission of this grant in an attempt to secure funds to further augment partnership activities. The major aim of this grant proposal is to continue the development of a sustainable partnership between HUCC and JHCCC that enhances the research, training, education, and outreach missions of both institutions. To accomplish this goal, the HUCC/JHCCC partnership will work to build the research faculty and scientific programs at HUCC directed at cancer in African-Americans, to enhance population-based cancer studies at JHCCC involving African-Americans, to increase opportunities for research training and career development of African-American career researchers at HUCC, and to improve education and outreach programs at JHCCC focused on career morbidity and mortality among African- Americans. The proposal seeks support for 3 research projects, 2 pilot research proj4ects, 1 pilot educational program, and core infrastructure at HUCC, along with additional funds for further planning and development of the HUCC/JHCCC partnership. Over the 5 years of support requested for the HUCC/JHCCC partnership, as these initial research and educational activities progress to compete for independent funding, new projects, programs, and resources of high priority for development will be identified and supported.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA091431-01
Application #
6336083
Study Section
Special Emphasis Panel (ZCA1-SRRB-5 (J1))
Program Officer
Springfield, Sanya A
Project Start
2001-07-13
Project End
2006-04-30
Budget Start
2001-07-13
Budget End
2002-04-30
Support Year
1
Fiscal Year
2001
Total Cost
$1,551,987
Indirect Cost
Name
Howard University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059
Khan, Farhan; Ricks-Santi, Luisel J; Zafar, Rabia et al. (2018) Expression of p27 and c-Myc by immunohistochemistry in breast ductal cancers in African American women. Ann Diagn Pathol 34:170-174
Khan, Farhan; Esnakula, Ashwini; Ricks-Santi, Luisel J et al. (2018) Loss of PTEN in high grade advanced stage triple negative breast ductal cancers in African American women. Pathol Res Pract 214:673-678
Ricks-Santi, Luisel; McDonald, J Tyson; Gold, Bert et al. (2017) Next Generation Sequencing Reveals High Prevalence of BRCA1 and BRCA2 Variants of Unknown Significance in Early-Onset Breast Cancer in African American Women. Ethn Dis 27:169-178
Nesoff, Elizabeth D; Milam, Adam J; Bone, Lee R et al. (2017) Tobacco policies and on-premise smoking in bars and clubs that cater to young African Americans following the Maryland Clean Indoor Air Act of 2007. J Ethn Subst Abuse 16:328-343
Weber, Kari A; Heaphy, Christopher M; Rohrmann, Sabine et al. (2016) Influence of In Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer? Prostate Cancer 2016:3691650
Ricks-Santi, Luisel J; Thompson, Nicole; Ewing, Altovise et al. (2016) Predictors of Self-Reported Family Health History of Breast Cancer. J Immigr Minor Health 18:1175-82
Akinboye, Emmanuel S; Bamji, Zebalda D; Kwabi-Addo, Bernard et al. (2015) Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines. Bioorg Med Chem 23:5839-45
Bamji, Zebalda D; Washington, Kareem N; Akinboye, Emmanuel et al. (2015) Apoptotic Effects of Novel Dithiocarbamate Analogs of Emetine in Prostate Cancer Cell Lines. Anticancer Res 35:4723-32
Ewing, Altovise; Thompson, Nicole; Ricks-Santi, Luisel (2015) Strategies for enrollment of African Americans into cancer genetic studies. J Cancer Educ 30:108-15
Kanaan, Yasmine M; Sampey, Brante P; Beyene, Desta et al. (2014) Metabolic profile of triple-negative breast cancer in African-American women reveals potential biomarkers of aggressive disease. Cancer Genomics Proteomics 11:279-94

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