Tobacco is the leading cause and alcohol is the third leading cause of preventable death and disability inthe U.S. Almost one-third of all cancers are directly attributable to smoking, and alcohol increases the risk forcancers of the mouth, pharynx, larynx, esophagus, liver, colon, rectum, and breast. Moreover, the concomitantuse of tobacco and alcohol synergistically increases the risk for some cancers (e.g., head and neck). Not onlyare tobacco and alcohol use major public health problems in their own right, they are closely linked behaviors.Smokers are much more likely to drink than are non-smokers and the prevalence of problem drinking is muchhigher among smokers than among nonsmokers.Unfortunately, tobacco and alcohol use are major public health problems in Puerto Rico (PR). Although theprevalence of smoking among Puerto Ricans living in PR is lower (12.5%) than in the continental U.S. (20.6%),the five leading causes of death in PR are associated with smoking (i.e., heart disease, cancer, stroke,hypertension and chronic pulmonary disease). Similarly, although Puerto Ricans are less likely to drink than iseither the general population of the U.S. or Hispanics in the U.S., they are more likely to be binge drinkers ifthey do drink (www.cdc.gov/brfss/). Furthermore, the negative health consequences of alcohol andtobacco are not confined strictly to heavy or abusive use. For example, the risk for each of the alcohol-relatedcancers increases substantially with alcohol consumption of more than two drinks per day for men, and onedrink per day for women. In fact, a landmark report from the Institute of Medicine (IOM) identified 'at risk'drinking (chronic moderate to heavy levels of use, binge drinking, or drinking and driving) as a serious publichealth concern because it is associated with numerous other negative health and social consequences, as wellas cancer. Therefore, the IOM recommended integrating screening, prevention, and treatment of at riskdrinking into public health settings. Thus, a critical strategy for cancer risk reduction among Puerto Ricansmokers is reducing the use of these two substances.The proposed study is a randomized clinical trial that will evaluate the efficacy of a unique, theoretically- andempirically-based 'Motivation and Problem-Solving' (MAPS) approach to treating tobacco and at risk alcoholuse in a population-based, public health setting. MAPS is a treatment approach that combines attributes ofboth motivational interviewing and cognitive behavioral/problem-solving treatment approaches. Participants arePuerto Rican smokers who are also 'at risk' drinkers, and who call the Puerto Rico Quitline (PRO) for smokingcessation counseling. At risk drinking, as defined by the National Institute on Alcohol Abuse and Alcoholism,refers to a constellation of alcohol use behaviors that increase risk for physical and psychosocial problems.Our previous research among smokers calling the PRO indicates that 36% are at risk drinkers.Participants (N=200) will be randomly assigned to either a MAPS treatment with a focus on smokingcessation, or a MAPS+ condition that focuses on smoking cessation and the reduction of at risk alcohol use.Treatment is telephone-based, and designed to be easily disseminated to health care systems and otherpopulation-based settings for tobacco and alcohol control. The primary outcome variable is at risk drinking. Wehypothesize that MAPS+ will reduce at risk alcohol use behaviors relative to MAPS. Although we will alsoexamine smoking cessation as an outcome, we believe that there will be no difference between MAPS andMAPS+ with respect to smoking cessation outcomes. Although Ml and cognitive behavioral/problem-solvingapproaches have a relatively long history in the treatment of alcohol use and smoking cessation, to the best ofour knowledge, this study would be the first to apply a motivational enhancement approach to concomitantlytreating smoking and alcohol use. It is important to note that the goal of MAPS+ is not necessarily to promoteabstinence from alcohol, but to modify at risk drinking behaviors.
The specific aims of this project are to:1. Evaluate MAPS and MAPS+ effects on at risk alcohol use (and smoking cessation) among PuertoRican smokers who are also at risk drinkers.2. Assess MAPS and MAPS+ effects on treatment mechanisms and the role of those mechanisms inmediating treatment effects on at risk drinking (and smoking cessation).3. Evaluate the cost-effectiveness of MAPS and MAPS+ in the reduction of at risk drinking (and smokingcessation).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54CA096297-06A1
Application #
7620208
Study Section
Special Emphasis Panel (ZCA1-SRRB-K (O1))
Project Start
2008-09-01
Project End
2011-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
6
Fiscal Year
2008
Total Cost
$112,814
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Type
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
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