TITLE: Pilot Project D - Anticancer Effect of Novel Compounds Derived from Gorgonian Octocorals inthe Caribbean SeaJO-LEADERS: UPRCCC - Abimael Rodriguez, Ph.D., Professor, Department of ChemistryMDACC - Yasuko Kondo, M.D., Ph.D., Assistant Professor, Neurosurgery-ResearchABSTRACTIn a pre-pilot study funded by the present U54 grant, we found that eupalmerin acetate (EPA), which wasselected from 15 compounds derived from marine organisms in the Caribbean Sea, has significant anticancereffect on human malignant glioma cells both in vitro and in vivo. We have also demonstrated that EPA inducesapoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase (JNK) pathway. As a successfulextension of our pre-pilot project, we have modified the structure of EPA and synthesized 10 additional EPAderivedcompounds to develop even more potent anticancer agents. We hypothesize that EPA or itsderivatives (collectively referred to as EPAs) will show anticancer effect in malignant qlioma and leukemia cellsboth in vitro and in vivo. Therefore, the objectives of this pilot project are 1) to determine the anticancer efficacyand mechanisms of EPAs in malignant glioma and leukemia cells in vitro, 2) to determine the anticancer effectof the lead compounds in the animal cancer xenograft model, and 3) to examine pharmacokinetics and toxicityof the lead compounds.Relevance of Pilot Project to the Overall PrioritiesThe goal of this proposal is to develop marine compounds isolated from the Caribbean Sea by an establishedscientist (UPR-Rio Piedras) into novel anticancer agents through collaboration of cancer specialists atMDACC. Our study is tightly associated with the U54 aims as the Co-leaders seek to continue building theirexisting partnership that started with a pre-pilot (pipeline) project.
Juan-Rivera, Maylein C; Martínez-Ferrer, Magaly (2018) Integrin Inhibitors in Prostate Cancer. Cancers (Basel) 10: |
Cruz-Correa, Marcia; Hylind, Linda M; Marrero, Jessica Hernandez et al. (2018) Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis. Gastroenterology 155:668-673 |
Gonzalez-Mercado, Velda J; Fridley, Brooke L; Saligan, Leorey N (2018) Sestrin family of genes and their role in cancer-related fatigue. Support Care Cancer 26:2071-2074 |
Villar-Prados, Alejandro; Wu, Sherry Y; Court, Karem A et al. (2018) Predicting novel therapies and targets: Regulation of Notch3 by the bromodomain protein BRD4. Mol Cancer Ther : |
Allen, Julie K; Armaiz-Pena, Guillermo N; Nagaraja, Archana S et al. (2018) Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction. Cancer Res 78:3233-3242 |
Marqués-Lespier, Juan M; Soto-Salgado, Marievelisse; González-Pons, María et al. (2018) Prevalence of Synchronous Oligopolyposis in Incident Colorectal Cancer: A Population-Based Study. P R Health Sci J 37:39-45 |
Maldonado, María Del Mar; Dharmawardhane, Suranganie (2018) Targeting Rac and Cdc42 GTPases in Cancer. Cancer Res 78:3101-3111 |
González-Pons, María; Soto-Salgado, Marievelisse; Sevilla, Javier et al. (2018) Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population-based study. Helicobacter 23: |
Monroig-Bosque, Paloma Del C; Shah, Maitri Y; Fu, Xiao et al. (2018) OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers. Sci Rep 8:13106 |
Das, Soma; Parga, Kenia; Chakraborty, Indranil et al. (2018) Magnetic resonance imaging contrast enhancement in vitro and in vivo by octanuclear iron-oxo cluster-based agents. J Inorg Biochem 186:176-186 |
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