C1. Objectives, Specific Aims and Approaches The Developmental Core of the MSM/TU/UAB CCC Partnership is responsible for overseeing program activities and for establishing new projects. This Core consists of the Cancer Research Program (CRP), the Cancer Training Program (CTP), the Cancer Outreach Program (COP), and the Cancer Education Program (CEP). The Core is directed by the Principal Investigators under the guidance of the Internal Advisory Committee (lAC) and the Partnership Advisory Council (PAC). The CRP provides: (a) Funding opportunities initially for two full and two pilot research projects and for additional pilot research projects, in years 4 and 5, that demonstrate the capability to become full research projects within the Partnership or, after completion, to achieve independent funding;(b) Effective mentors for junior faculty co-leaders who, as part of the Partnership, have received pilot or full research project funding; and (c) Regular evaluation of projects and mentors to ensure success ofthe individual projects and the overall effectiveness of the CRP. The CTP is responsible for development and implementation of cancer research training and career development of postdoctoral fellows, junior and transitional faculty as well as graduate students. The COP educates and mobilizes communities to take action to prevent and control cancer. It is also responsible for designing, implementing, and refining the Patient Navigator Program for increasing minority participation in clinical trials. The CEP is responsible for design, administration, and evaluation of educational programs/courses on health disparities targeting graduate/undergraduate students, high school teachers, and students as well as implementation/evaluation of the Cancer Partnership Interns Program targeting undergraduate students. The programs of the Developmental Core are supported by the Bioethics Shared Resource to provide training and education in the principles of bioethics to mentors, junior faculty, postdoctoral fellows, graduate students, community partners, community health advisors/patient navigators, and staff members, and by the Biostatistics Shared Resource, which provides biostatistical consultation in study design, data management, and statistical analysis for the research activities of this Core.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA118948-09
Application #
8936039
Study Section
Special Emphasis Panel (ZCA1-SRLB-Y (O1))
Program Officer
Ogunbiyi, Peter
Project Start
2014-09-01
Project End
2016-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
9
Fiscal Year
2014
Total Cost
$507,196
Indirect Cost
$158,299
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Luo, Yanzhuo; Li, Bingjin; Zhang, Guangxin et al. (2018) Integrated Oncogenomic Profiling of Copy Numbers and Gene Expression in Lung Adenocarcinomas without EGFR Mutations or ALK Fusion. J Cancer 9:1096-1105
Wang, Chiung-Min; Yang, William H; Liu, Runhua et al. (2018) FOXP3 Activates SUMO-Conjugating UBC9 Gene in MCF7 Breast Cancer Cells. Int J Mol Sci 19:
Moore, Justin Xavier; Royston, Kendra J; Langston, Marvin E et al. (2018) Mapping hot spots of breast cancer mortality in the United States: place matters for Blacks and Hispanics. Cancer Causes Control :
Akinyemiju, Tomi; Moore, Justin Xavier; Pisu, Maria et al. (2018) A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality. Obesity (Silver Spring) 26:193-201
Akinyemiju, Tomi; Moore, Justin Xavier; Judd, Suzanne E et al. (2018) Pre-diagnostic biomarkers of metabolic dysregulation and cancer mortality. Oncotarget 9:16099-16109
Zhang, Yifan; Li, Bingjin; Zhang, Xingyi et al. (2017) CD24 is a genetic modifier for risk and progression of prostate cancer. Mol Carcinog 56:641-650
Moore, Justin Xavier; Chaudhary, Ninad; Akinyemiju, Tomi (2017) Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988-2012. Prev Chronic Dis 14:E24
Kaye, Savannah; Zeng, Zheng; Sanders, Mollye et al. (2017) Label-free detection of DNA hybridization with a compact LSPR-based fiber-optic sensor. Analyst 142:1974-1981
Zhang, Guangxin; Zhang, Wei; Li, Bingjin et al. (2017) MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Res 19:73
Moore, Justin Xavier; Akinyemiju, Tomi; Wang, Henry E (2017) Pollution and regional variations of lung cancer mortality in the United States. Cancer Epidemiol 49:118-127

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