Abstract

Protein-protein interactions are an integral component of many sections of this proposal. This DBP focuses on an important family of proteins, the cadherins, whose binding specificity plays a central role in cell-cell adhesion. Our goal is to understand the molecular basis of the binding specificity of cadherins and, in turn, the structural basis of many cell-cell adhesion processes. The fundamental question to be addressed concerns how cadherins are able to bind to one another at the cellular level in a homophilic fashion, even though many cadherins are closely related to one another in sequence, and thus might be expected to cross-react. Indeed heterophilic binding is sometimes observed in in-vitro measurements. In addition, we wish to understand the diverse function of different cadherins and to see how different cadherin subfamilies have evolved to carry out distinct, albeit related functions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA121852-04
Application #
7676858
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
4
Fiscal Year
2008
Total Cost
$284,261
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Hui, Ken Y; Fernandez-Hernandez, Heriberto; Hu, Jianzhong et al. (2018) Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med 10:
Azad, Robert N; Zafiropoulos, Dana; Ober, Douglas et al. (2018) Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations. Nucleic Acids Res 46:2636-2647
Abe, Takayuki; Lee, Albert; Sitharam, Ramaswami et al. (2017) Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization. Immunity 46:621-634
Wang, Donglai; Kon, Ning; Lasso, Gorka et al. (2016) Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature 538:118-122
Hosios, Aaron M; Hecht, Vivian C; Danai, Laura V et al. (2016) Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell 36:540-9
Stockman, Victoria B; Ghamsari, Lila; Lasso, Gorka et al. (2016) A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions. PLoS One 11:e0167617
Alvarez, Mariano J; Shen, Yao; Giorgi, Federico M et al. (2016) Functional characterization of somatic mutations in cancer using network-based inference of protein activity. Nat Genet 48:838-47
Sheng, Ren; Jung, Da-Jung; Silkov, Antonina et al. (2016) Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain. J Biol Chem 291:17639-50
Lachmann, Alexander; Giorgi, Federico M; Lopez, Gonzalo et al. (2016) ARACNe-AP: gene network reverse engineering through adaptive partitioning inference of mutual information. Bioinformatics 32:2233-5
Park, Mi-Jeong; Sheng, Ren; Silkov, Antonina et al. (2016) SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins. Mol Cell 62:7-20

Showing the most recent 10 out of 258 publications